ArticleInternational journal of obesity (2005)2019
Childhood sleep duration modifies the polygenic risk for obesity in youth through leptin pathway: the Beijing Child and Adolescent Metabolic Syndrome cohort study.
Article in International journal of obesity (2005), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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23 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Sleep duration is associated with metabolic syndrome in adolescents and children: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Pooled it
- Cardiometabolic and Biochemical Indicators in Adolescent Girls According to Nutritional Status and Lifestyle.Nutrients · 2026Article
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- Assessment of Sleep Quality in Adolescents with Overweight and Obesity Using the Adolescent Sleep Hygiene Scale (ASHS).Children (Basel, Switzerland) · 2024Article
- 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.medRxiv : the preprint server for health sciences · 2024Article
- Childhood sleep: physical, cognitive, and behavioral consequences and implications.World journal of pediatrics : WJP · 2024Review
- Insulin Resistance in Pediatric Obesity: From Mechanisms to Treatment Strategies.Pediatric diabetes · 2024Review
- Longitudinal reallocations of time between 24-h movement behaviours and their associations with inflammation in children and adolescents: the UP&DOWN study.The international journal of behavioral nutrition and physical activity · 2023Article
- Obesity in children and adolescents: Overview of the diagnosis and management.Chronic diseases and translational medicine · 2023Review
- Physical Activity Levels and Sleep in Schoolchildren (6-17) with and without School Sport.International journal of environmental research and public health · 2023Article
- Genetics of circadian rhythms and sleep in human health and disease.Nature reviews. Genetics · 2023Review
- Adipokines in Sleep Disturbance and Metabolic Dysfunction: Insights from Network Analysis.Clocks & sleep · 2022Article
- Obese Patients Experience More Severe CSA than Non-Obese Patients.International journal of environmental research and public health · 2022Article
- A longitudinal study of sleep, weight status, and weight-related behaviors: Childhood Obesity Study in China Mega-cities.Pediatric research · 2021Article
- Cardiovascular Disease Prevention in Adolescence: New Possibilities.Arquivos brasileiros de cardiologia · 2021Article
- Association between sleep duration and asthma in different weight statuses (CHNS 2009-2015).Sleep & breathing = Schlaf & Atmung · 2021Article
- Lifestyle Risk Factors and the Population Attributable Fractions for Overweight and Obesity in Chinese Students of Zhejiang Province.Frontiers in pediatrics · 2021Article
- Machine and Deep Learning in Molecular and Genetic Aspects of Sleep Research.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Puberty Status Modifies the Effects of Genetic Variants, Lifestyle Factors and Their Interactions on Adiponectin: The BCAMS Study.Frontiers in endocrinology · 2021Article
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
objectivesShort sleep is an obesity risk factor, however, little is known about its interplay with genetic predisposition and pathways involved in obesity pathogenesis, especially in the longitudinal setting. We aimed to investigate a possible sleep-gene interaction for childhood obesity risk, and whether the interaction in childhood longitudinally contributes to obesity risk at a 10-year follow-up and further to test if there is any mediation through the leptin pathway. SUBJECTS/
methodsA total of 3211 children from China (6-18 years) at baseline and 848 participants at 10-year follow-up from the Beijing Child and Adolescent Metabolic Syndrome (BCAMS) cohort study were analyzed. Baseline leptin concentrations and 12 established adult body mass index (BMI) loci were examined for the associations with habitual sleep duration.
resultsAfter adjusting for covariates, including pubertal stages and behavioral factors, short sleep duration at baseline was significantly associated with increased overweight/obesity risk at both baseline and follow-up. Genetic predisposition scores (GPS), particularly consisting of leptin-related SNPs (GPS
conclusionsThis study suggests that shorter sleep duration in children from China (< 8h/day), compared to longer sleep duration (≥10 h/day), has a long-term impact on the association of polygenic risk for obesity from childhood to young adulthood and leptin pathway explains a key mechanism via a modification effect. Therefore, adequate sleep duration during childhood is important for the early prevention of obesity, especially if there is a genetic predisposition to this trait.
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