Evidence map›Paper›PMID 31285464›Full record

ArticleScientific reports2019

High throughput development of TCR-mimic antibody that targets survivin-2B

Nobuyuki Kurosawa, Yuka Wakata, Kenta Ida, Aki Midorikawa, Masaharu Isobe

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  3. Article
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  5. Article
  6. Article
  7. Identification of Neoantigens in Cancer Cells as Targets for Immunotherapy.International journal of molecular sciences · 2022
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Bispecific antibodies in cancer immunotherapy.Current opinion in biotechnology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nobuyuki KurosawaLaboratory of Molecular and Cellular Biology, Faculty of Science and Engineering, Graduate School, University of Toyama, 3190 Gofuku, Toyama-shi, Toyama, 930-8555, Japan. kurosawa@eng.u-toyama.ac.jp.
Yuka WakataFrontier Research Core for Life Sciences, University of Toyama, 3190 Gofuku, Toyama-shi, Toyama, 930-8555, Japan.
Kenta IdaGraduate School of Science and Engineering for Education, University of Toyama, Toyama-shi, Toyama, 930-8555, Japan.
Aki MidorikawaGraduate School of Science and Engineering for Education, University of Toyama, Toyama-shi, Toyama, 930-8555, Japan.
Masaharu IsobeLaboratory of Molecular and Cellular Biology, Faculty of Science and Engineering, Graduate School, University of Toyama, 3190 Gofuku, Toyama-shi, Toyama, 930-8555, Japan. isobe@eng.u-toyama.ac.jp.
University of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracellular tumor-associated antigens are targeted by antibodies known as T-cell receptor mimic antibodies (TCRm-Abs), which recognize T-cell epitopes with better stabilities and higher affinities than T-cell receptors. However, TCRm-Abs have been proven difficult to produce using conventional techniques. Here, we developed TCRm-Abs that recognize the survivin-2B-derived nonamer peptide, AYACNTSTL (SV2B

Indexed as

AnimalsAntibodies, BispecificCell SeparationEpitopes, T-LymphocyteFlow CytometryHeLa CellsHigh-Throughput Screening AssaysHLA-A24 AntigenHumansImmunizationLeukocytes, MononuclearMiceReceptors, Antigen, T-CellSurvivinAntibodies, BispecificBIRC5 protein, humanEpitopes, T-LymphocyteHLA-A24 AntigenReceptors, Antigen, T-CellSurvivin

Identifiers

PMID31285464
PMCPMC6614450
OpenAlexW2962171803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.