ArticleNature communications2019
The effect of X-linked dosage compensation on complex trait variation.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Better together against genetic heterogeneity: A sex-combined joint main and interaction analysis of 290 quantitative traits in the UK Biobank.PLoS genetics · 2024Pooled it
- Boosting the power of genome-wide association studies within and across ancestries by using polygenic scores.Nature genetics · 2023Pooled it
- Article
- Sex-linked placental DNA methylation associated with early-onset preeclampsia.Research square · 2026Article
- geneXplore: An Interactive Browser for X Chromosome-Wide Association Study Results.medRxiv : the preprint server for health sciences · 2026Article
- Modeling rare coding variation on chromosome X provides insight into the genetics and differential sex prevalence of autism spectrum disorder.medRxiv : the preprint server for health sciences · 2026Article
- Escape from X inactivation drives sex differences in gene expression.Molecular biology and evolution · 2026Article
- Article
- Insights into X-Linked Susceptibility to Parkinson's Disease in the South African Population.medRxiv : the preprint server for health sciences · 2025Article
- X chromosome inactivation across primary human tissues is mostly complete, with significant implications for genetic and clinical studies.BMC genomics · 2025Article
- Leveraging multiomic approaches to elucidate mechanisms of heterogeneity in Alzheimer's disease: Neuropsychiatric symptoms, co-pathologies, and sex differences.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- BIGFAM - variance components analysis from relatives without genotype.Nature communications · 2025Article
- Role of X chromosome and dosage-compensation mechanisms in complex trait genetics.American journal of human genetics · 2025Article
- X-Linked Gene Dosage and SOX2 Act as Key Roadblocks for Human Germ Cell Specification in Klinefelter Syndrome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration.Nature communications · 2025Article
- The X chromosome's influences on the human brain.Science advances · 2025Article
- Genetic parameters and genome-wide association studies including the X chromosome for various reproduction and semen quality traits in Nellore cattle.BMC genomics · 2025Article
- Inter-chromosomal contacts demarcate genome topology along a spatial gradient.Nature communications · 2024Article
- Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences.Nature genetics · 2024Article
- Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues.Cell genomics · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Quantitative genetics theory predicts that X-chromosome dosage compensation (DC) will have a detectable effect on the amount of genetic and therefore phenotypic trait variances at associated loci in males and females. Here, we systematically examine the role of DC in humans in 20 complex traits in a sample of more than 450,000 individuals from the UK Biobank and 1600 gene expression traits from a sample of 2000 individuals as well as across-tissue gene expression from the GTEx resource. We find approximately twice as much X-linked genetic variation across the UK Biobank traits in males (mean h
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