Evidence map›Paper›PMID 31285342›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Adaptation by naïve CD4

Wendy M Zinzow-Kramer, Arthur Weiss, Byron B Au-Yeung

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 67 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. A review of CD4Veterinary immunology and immunopathology · 2024
    Review
  14. The amalgam of naive CD4Immunity · 2024
    Article
  15. Article
  16. Article
  17. An inference model gives insights into innate immune adaptation and repertoire diversity.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Review
  19. The TCR Cα Domain Regulates Responses to Self-pMHC Class II.Journal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Wendy M Zinzow-KramerDepartment of Medicine, Division of Immunology, Lowance Center for Human Immunology, Emory University, Atlanta, GA 30322.
Arthur WeissDepartment of Medicine, Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, University of California, San Francisco, CA 94143; aweiss@medicine.ucsf.edu byron.au-yeung@emory.edu.
Byron B Au-YeungDepartment of Medicine, Division of Immunology, Lowance Center for Human Immunology, Emory University, Atlanta, GA 30322; aweiss@medicine.ucsf.edu byron.au-yeung@emory.edu.
Emory University · USHoward Hughes Medical Institute · US

Funding

Understand the metabolic fitness of naïve T cellsP01AI091580 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ARTHUR Robert SALOMON · 2011 to 2026
$31.1M
Inhibition of ZAP-70 to selectively attenuate autoimmune disease-inducing T cellsK01AR065481 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AU-YEUNG, BYRON BENTON · 2014 to 2016
$385k
NIAID NIH HHS P01 AI091580NIAMS NIH HHS K01 AR065481
6 · The paper itself

Abstract

Naïve CD4

Indexed as

Immune ToleranceAnimalsAntigens, LyAutoantigensCD4-Positive T-LymphocytesCD5 AntigensClonal AnergyGene Expression RegulationGenes, ReporterGreen Fluorescent ProteinsInterleukin-2Lymphocyte ActivationMiceMice, TransgenicNuclear Receptor Subfamily 4, Group A, Member 1OvalbuminAntigens, LyAutoantigensCD5 AntigensCd5 protein, mouseGreen Fluorescent ProteinsInterleukin-2Ly-6C antigen, mouseNr4a1 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1OvalbuminPeptidesReceptors, Antigen, T-CellTetradecanoylphorbol Acetatebasal TCR signalingCD5Nur77T cell activationT cell anergy

Identifiers

PMID31285342
PMCPMC6660790
OpenAlexW2958961855

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.