ArticleProceedings of the National Academy of Sciences of the United States of America2019
Telomere shortening rate predicts species life span.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
179 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The biological scaling of Alzheimer's disease neuropathological changes across primate species.Alzheimer's research & therapy · 2025Pooled it
- The association of metabolic syndrome with telomere length as a marker of cellular aging: a systematic review and meta-analysis.Frontiers in genetics · 2024Pooled it
- The effects of exercise and diet on oxidative stress and telomere length in breast cancer survivors.Breast cancer research and treatment · 2023Trial
- Energy constraint on human health.Trends in endocrinology and metabolism: TEM · 2026Review
- Biogeographic cline is associated with the global plant telomere length variation.bioRxiv : the preprint server for biology · 2026Article
- Health behaviours and telomere biology in severe mental disorders.Translational psychiatry · 2026Article
- Dilating the aging clock with light.Innovation (Cambridge (Mass.)) · 2026Review
- Impact of tobacco smoking on estimated telomere shortening and epigenetic age acceleration among human blood immune cell types.Clinical epigenetics · 2026Article
- Review
- Telomere biology and telomerase regulation across species: evolutionary insights into aging, longevity, and genome stability.Molecular biology reports · 2026Review
- A unifying model of stem cell dynamics explains age-related methylation patterns across mammals.Nature aging · 2026Article
- Longevity.Clinical medicine & research · 2026Review
- Telomere Length Is Determined by Intrinsic Factors and Is Shortened During Drought Years inEcology and evolution · 2026Article
- Article
- The adaptive molecular landscape of reprogrammed telomeric sequences.Nature communications · 2026Article
- Systematic Druggable Genome-Wide Analysis Identifies Therapeutic Targets for Aging: A Mendelian Randomization Study.Health science reports · 2026Article
- Protection of telomeres 1b safeguards the Arabidopsis genome by regulating ROS homeostasis.Nature communications · 2026Article
- Telomerase-active urine-derived stem cells: Regenerative solutions for aging.Ageing research reviews · 2026Review
- Molecular pathways linking chronic psychological stress to accelerated aging: mechanisms and interventions.Frontiers in aging · 2026Review
- CumulativeFrontiers in cellular and infection microbiology · 2026Article
119 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomere shortening to a critical length can trigger aging and shorter life spans in mice and humans by a mechanism that involves induction of a persistent DNA damage response at chromosome ends and loss of cellular viability. However, whether telomere length is a universal determinant of species longevity is not known. To determine whether telomere shortening can be a single parameter to predict species longevities, here we measured in parallel the telomere length of a wide variety of species (birds and mammals) with very different life spans and body sizes, including mouse (
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Registered trials
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