Evidence map›Paper›PMID 31285252›Full record

ArticleInfection and immunity2019

Development of Opsonic Mouse Monoclonal Antibodies against Multidrug-Resistant Enterococci.

Ermioni Kalfopoulou, Diana Laverde, Karmela Miklic, Felipe Romero-Saavedra, Suzana Malic, Filippo Carboni, Roberto Adamo, Tihana Lenac Rovis, Stipan Jonjic, Johannes Huebner

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Enterococcal Membrane Vesicles as Vaccine Candidates.International journal of molecular sciences · 2023
    Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Ermioni KalfopoulouDivision of Paediatric Infectious Diseases, Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany.ORCID 0000-0002-4125-5101
Diana LaverdeDivision of Paediatric Infectious Diseases, Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany.
Karmela MiklicCenter for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Felipe Romero-SaavedraDivision of Paediatric Infectious Diseases, Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany.
Suzana MalicCenter for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Filippo CarboniGSK, Siena, Italy.
Roberto AdamoGSK, Siena, Italy.
Tihana Lenac RovisCenter for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Stipan JonjicCenter for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Johannes HuebnerDivision of Paediatric Infectious Diseases, Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany johannes.huebner@med.uni-muenchen.de.
Ludwig-Maximilians-Universität München · DEUniversity of Rijeka · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug-resistant enterococci are major causes of hospital-acquired infections. Immunotherapy with monoclonal antibodies (MAbs) targeting bacterial antigens would be a valuable treatment option in this setting. Here, we describe the development of two MAbs through hybridoma technology that target antigens from the most clinically relevant enterococcal species. Diheteroglycan (DHG), a well-characterized capsular polysaccharide of

Indexed as

Drug Resistance, MicrobialAnimalsAntibodies, MonoclonalAntigens, BacterialBacterial CapsulesEnterococcus faecalisEnterococcus faeciumImmunotherapyMiceOpsonin ProteinsPolysaccharidesAntibodies, MonoclonalAntigens, BacterialOpsonin ProteinsPolysaccharidescapsular polysaccharideDHGdiheteroglycanEnterococcus faecalisEnterococcus faeciumhybridoma technologymonoclonal antibodiesopsonicopsonophagocytic assaySagA

Identifiers

PMID31285252
PMCPMC6704603
OpenAlexW2957105212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.