Evidence map›Paper›PMID 31285232›Full record

ArticleAntimicrobial agents and chemotherapy2019

Spheroplast-Mediated Carbapenem Tolerance in Gram-Negative Pathogens.

Trevor Cross, Brett Ransegnola, Jung-Ho Shin, Anna Weaver, Kathy Fauntleroy, Michael S VanNieuwenhze, Lars F Westblade, Tobias Dörr

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 59 citations in OpenAlex.

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  13. Identification of the Major Facilitator Superfamily Efflux Pump KpsrMFS inInternational journal of molecular sciences · 2024
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  20. Prevalence of Antibiotic Tolerance and Risk for Reinfection Among Escherichia coli Bloodstream Isolates: A Prospective Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Trevor Cross *Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA.
Brett Ransegnola *Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA.
Jung-Ho ShinWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA.
Anna WeaverWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA.
Kathy FauntleroyDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA.
Michael S VanNieuwenhzeDepartment of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana, USA.
Lars F WestbladeDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA law9067@med.cornell.edu tdoerr@cornell.edu.
Tobias DörrWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA law9067@med.cornell.edu tdoerr@cornell.edu.ORCID 0000-0003-3283-9161
Cornell University · USIndiana University Bloomington · US

Funding

Dynamics of bacterial peptidoglycan synthesisR01GM113172 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI BRUN, YVES V, VANNIEUWENHZE, MICHAEL S · 2015 to 2018
$3.5M
Cell envelope stress responses and the mechanism of antibiotic tolerance in Gram-negative pathogensR01AI143704 · NIAID · CORNELL UNIVERSITY · PI DOERR, TOBIAS · 2019 to 2023
$2.0M
NIAID NIH HHS R01 AI143704NIGMS NIH HHS R01 GM113172
6 · The paper itself

Abstract

Antibiotic tolerance, the ability to temporarily sustain viability in the presence of bactericidal antibiotics, constitutes an understudied and yet potentially widespread cause of antibiotic treatment failure. We have previously shown that the Gram-negative pathogen

Indexed as

AmdinocillinAnti-Bacterial AgentsDrug ToleranceEnterobacter aerogenesEnterobacter cloacaeEscherichia coliGram-Negative Bacterial InfectionsKlebsiella pneumoniaeMeropenemMicrobial Sensitivity TestsSpheroplastsAmdinocillinAnti-Bacterial AgentsMeropenemantibioticcarbapenemcarbapenemaseL-formmeropenemtolerance

Identifiers

PMID31285232
PMCPMC6709500
OpenAlexW2959383915

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.