Evidence map›Paper›PMID 31285231›Full record

ArticleAntimicrobial agents and chemotherapy2019

Genomic Analysis Identifies Novel Pseudomonas aeruginosa Resistance Genes under Selection during Inhaled Aztreonam Therapy

Kathryn McLean, Duankun Lee, Elizabeth A Holmes, Kelsi Penewit, Adam Waalkes, Mingxin Ren, Samuel A Lee, Joseph Gasper, Colin Manoil, Stephen J Salipante

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Tracing the evolutionary trajectory of the IncP-2 plasmid co-harboringFrontiers in cellular and infection microbiology · 2025
    Article
  5. Impact of repeatedFrontiers in microbiology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. β-lactam Resistance inPathogens (Basel, Switzerland) · 2021
    Review
  13. Antibiotics (Basel, Switzerland) · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Quest for Novel Preventive and Therapeutic Options Against Multidrug-ResistantInternational journal of peptide research and therapeutics · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kathryn McLeanDepartment of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Duankun LeeDepartment of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Elizabeth A HolmesDepartment of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Kelsi PenewitDepartment of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Adam WaalkesDepartment of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Mingxin RenDepartment of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Samuel A LeeDepartment of Genome Sciences, University of Washington, Seattle, Washington, USA.
Joseph GasperDepartment of Genome Sciences, University of Washington, Seattle, Washington, USA.
Colin ManoilDepartment of Genome Sciences, University of Washington, Seattle, Washington, USA.
Stephen J SalipanteDepartment of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, USA stevesal@uw.edu.
University of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhaled aztreonam is increasingly used for chronic

Indexed as

Administration, InhalationAnti-Bacterial AgentsAztreonamBacterial Proteinsbeta-Lactamasesbeta-Lactam ResistanceCystic FibrosisDNA Transposable ElementsGene ExpressionHumansMutationPeptidoglycan GlycosyltransferasePseudomonas aeruginosaPseudomonas InfectionsSelection, GeneticAmpC beta-lactamasesAnti-Bacterial AgentsAztreonamBacterial Proteinsbeta-LactamasesDNA Transposable ElementsPeptidoglycan GlycosyltransferaseampCantibiotic resistanceaztreonamcystic fibrosisgenome analysisPseudomonas aeruginosaselectionβ-lactamase

Identifiers

PMID31285231
PMCPMC6709462
OpenAlexW2954711774

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.