Evidence map›Paper›PMID 31284924›Full record

ReviewImmunology and allergy clinics of North America2019

Rhinovirus and Asthma Exacerbations.

Joshua L Kennedy, Sarah Pham, Larry Borish

Open access · greenAbstract readReview
In one paragraph

Review in Immunology and allergy clinics of North America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Non-T2 asthma.Current opinion in pulmonary medicine · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. iScience · 2021
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Joshua L KennedyDepartment of Pediatrics, University of Arkansas for Medical Sciences, 13 Children's Way, Slot 512-13, Little Rock, AR 72202, USA; Department of Internal Medicine, University of Arkansas for Medical Sciences, 13 Children's Way, Slot 512-13, Little Rock, AR 72202, USA; Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, 13 Children's Way, Slot 512-13, Little Rock, AR 72202, USA. Electronic address: kennedyjoshual@uams.edu.
Sarah PhamDepartment of Pediatrics, University of Arkansas for Medical Sciences, 13 Children's Way, Slot 512-13, Little Rock, AR 72202, USA.
Larry BorishDepartment of Medicine, University of Virginia Health Systems, MR4 Building Room 5041, 409 Lane Road, Charlottesville, VA 22903, USA; Department of Microbiology, University of Virginia Health Systems, MR4 Building Room 5041, 409 Lane Road, Charlottesville, VA 22903, USA; Carter Immunology Center, University of Virginia Health Systems, MR4 Building Room 5041, 409 Lane Road, Charlottesville, VA 22903, USA.
University of Arkansas for Medical Sciences · USUniversity of Virginia Health System · US

Funding

Translational Regulation in Normal Erythropoiesis and Diamond Blackfan AnemiaP20GM121293 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Alan Tackett · 2017 to 2026
$27.6M
Expanding Translational Research in ArkansasUL1TR003107 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2019 to 2023
$21.6M
Arkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0M
Clinical response to rhinovirus challenge in human asthmaticsU01AI123337 · NIAID · UNIVERSITY OF VIRGINIA · PI BORISH, LARRY C · 2016 to 2020
$3.6M
Examining Mechanisms of Synergy between Asthma Exacerbations and RV InfectionK08AI121345 · NIAID · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI KENNEDY, JOSHUA · 2016 to 2020
$949k
Arkansas Center for Clinical Translational ResearchKL2TR000063 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$459k
NCATS NIH HHS KL2 TR000063NCATS NIH HHS UL1 TR000039NCATS NIH HHS UL1 TR003107NIAID NIH HHS K08 AI121345NIAID NIH HHS U01 AI123337NIGMS NIH HHS P20 GM121293
6 · The paper itself

Abstract

Rhinovirus (RV) is ubiquitous and typically causes only minor upper respiratory symptoms. However, especially in children and adolescent asthmatics, RV is responsible for most exacerbations. This ability of RV to drive exacerbations typically requires the concomitant presence of exposure to a bystander allergen. Susceptibility to RV-mediated exacerbations is also related to the genetic background of the host, which contributes to greater infectivity, more severe infections, altered immune responses, and to greater inflammation and loss of asthma control. Given these responses, there are several treatments available or being developed that should improve the control of exacerbations related to RV infection.

Indexed as

AllergensAnimalsAsthmaDisease ProgressionDisease SusceptibilityGenetic Predisposition to DiseaseHost-Pathogen InteractionsHumansHypersensitivityPicornaviridae InfectionsRhinovirusAllergensAllergyAsthmaGeneticsIgERhinovirus

Identifiers

PMID31284924
PMCPMC6625523
OpenAlexW2945234732

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.