Evidence map›Paper›PMID 31284923›Full record

ReviewImmunology and allergy clinics of North America2019

Importance of Virus Characteristics in Respiratory Syncytial Virus-Induced Disease.

Homero San-Juan-Vergara, Mark E Peeples

Open access · greenAbstract readReview
In one paragraph

Review in Immunology and allergy clinics of North America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Homero San-Juan-VergaraDivision of Health Sciences, Fundación Universidad del Norte, Universidad del Norte, Bloque de Salud, Cuarto Piso 4-25L4, Km 5. Via Puerto, Barranquilla 081007, Colombia.
Mark E PeeplesCenter for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA. Electronic address: mark.peeples@nationwidechildrens.org.
The Ohio State University · USUniversidad del Norte · CO

Funding

Project 3: Dr. LiP01AI112524 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI LI, JIANRONG · 2015 to 2019
$6.8M
Respiratory Syncytial Virus Targeting of the Human Airway EpitheliumR01AI093848 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI PEEPLES, MARK E. · 2012 to 2023
$3.8M
Mechanism of Respiratory Syncytial Virus FusionR01AI095684 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI PEEPLES, MARK E. · 2012 to 2016
$1.5M
Mechanism of Respiratory Syncytial Virus Entry in Normal Human Bronchial EpitheliR01AI110385 · NIAID · UNIVERSITY DEL NORTE · PI SAN JUAN VERGARA, HOMERO GABRIEL · 2014 to 2018
$552k
Mechanism of Respiratory Syncytial Virus FusionR56AI095684 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI PEEPLES, MARK E. · 2011 to 2011
$362k
NIAID NIH HHS P01 AI112524NIAID NIH HHS R01 AI093848NIAID NIH HHS R01 AI095684NIAID NIH HHS R01 AI110385NIAID NIH HHS R56 AI095684
6 · The paper itself

Abstract

Severe lower respiratory tract infection in infants and young children is most frequently caused by respiratory syncytial virus (RSV). RSV infects the smallest airways, making breathing difficult and in some infants requiring medical support. Severity is affected by viral dose, infant age, virus genotype, and effectiveness of the innate/adaptive immune responses. Severe disease correlates with later wheezing and asthma in some children. The adaptive immune response is protective but wanes after each infection, likely due to the ability of the RSV NS1/NS2 proteins to inhibit the innate immune response. Several vaccine approaches and candidates are currently in clinical trials.

Indexed as

Antigens, ViralHost-Pathogen InteractionsHumansImmunity, InnateRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsSeverity of Illness IndexViral ProteinsViral VaccinesVirus AssemblyAntigens, ViralViral ProteinsViral VaccinesGenotypesG proteinNeutralizing antibodyPostfusionPrefusionRespiratory syncytial virus (RSV)Vaccine

Identifiers

PMID31284923
PMCPMC6879194
OpenAlexW2944873910

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.