Evidence map›Paper›PMID 31284746›Full record

ReviewFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

TGF-β1-p53 cooperativity regulates a profibrotic genomic program in the kidney: molecular mechanisms and clinical implications.

Craig E Higgins, Jiaqi Tang, Badar M Mian, Stephen P Higgins, Cody C Gifford, David J Conti, Kirstan K Meldrum, Rohan Samarakoon, Paul J Higgins

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. A Novel Mechanism of the p53 Isoform Δ40p53α in Regulating Collagen III Expression in TGFβ1-Induced LX-2 Human Hepatic Stellate Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. p53 and Myofibroblast Apoptosis in Organ Fibrosis.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Article
  13. Emerging role of tumor suppressor p53 in acute and chronic kidney diseases.Cellular and molecular life sciences : CMLS · 2022
    Review
  14. Article
  15. Review
  16. Mitochondrial Pathophysiology on Chronic Kidney Disease.International journal of molecular sciences · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Craig E HigginsDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, New York, USA.
Jiaqi TangDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, New York, USA.
Badar M MianThe Urological Institute of Northeastern New York, Albany, New York, USA.
Stephen P HigginsDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, New York, USA.
Cody C GiffordDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, New York, USA.
David J ContiDivision of Transplantation Surgery, Department of Surgery, Albany Medical College, Albany, New York, USA.
Kirstan K MeldrumDivision of Pediatric Urology, Central Michigan University, Mount Pleasant, Michigan, USA.
Rohan SamarakoonDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, New York, USA.
Paul J HigginsDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, New York, USA.
Albany Medical Center Hospital · USCentral Michigan University · USLions Eye Bank at Albany · USMultiple Sclerosis Center Of Northeastern New York · US

Funding

MATRIX MEDIATORS OF WOUND HEALINGR01GM057242 · NIGMS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI HIGGINS, PAUL J. · 1998 to 2010
$3.2M
NIGMS NIH HHS R01 GM057242
6 · The paper itself

Abstract

Chronic kidney disease affects >15% of the U.S. population and >850 million individuals worldwide. Fibrosis is the common outcome of many chronic renal disorders and, although the etiology varies (

Indexed as

Genes, p53AnimalsCellular MicroenvironmentFibrosisGene Expression RegulationGene Regulatory NetworksHumansKidneyModels, BiologicalPlasminogen Activator Inhibitor 1Renal Insufficiency, ChronicSignal TransductionSmad ProteinsTransforming Growth Factor beta1Tumor Suppressor Protein p53Plasminogen Activator Inhibitor 1SERPINE1 protein, humanSmad ProteinsTGFB1 protein, humanTP53 protein, humanTransforming Growth Factor beta1Tumor Suppressor Protein p53fibrosisgene expressionPAI-1renal diseaseSMADs

Identifiers

PMID31284746
PMCPMC6766640
OpenAlexW2960956325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.