Evidence map›Paper›PMID 31284699›Full record

ArticleJournal of clinical medicine2019

Phenotypic and Genotypic Characterization of

Jonas Abo Basha, Matthias Kiel, Dennis Görlich, Katharina Schütte-Nütgen, Anika Witten, Hermann Pavenstädt, Barbara C Kahl, Ulrich Dobrindt, Stefan Reuter

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Clinical epidemiology and case fatality due to antimicrobial resistance in Germany: a systematic review and meta-analysis, 1 January 2010 to 31 December 2021.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Natural Bred εAntibiotics (Basel, Switzerland) · 2021
    Article
  7. Molecular epidemiology of blaAnnals of clinical microbiology and antimicrobials · 2021
    Article
  8. Prevalence, serotyping and drug susceptibility patterns ofWorld journal of biological chemistry · 2020
    Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jonas Abo BashaDepartment of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital Münster, 48149 Münster, Germany.
Matthias KielInstitute of Hygiene, University of Münster, 48149 Münster, Germany.
Dennis GörlichInstitute of Biostatistics and Clinical Research, University of Münster, 48149 Münster, Germany.
Katharina Schütte-NütgenDepartment of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital Münster, 48149 Münster, Germany.
Anika WittenInstitute for Human Genetics, University of Münster, 48149 Münster, Germany.
Hermann PavenstädtDepartment of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital Münster, 48149 Münster, Germany.
Barbara C KahlInstitute of Medical Microbiology, University Hospital Münster, 48149 Münster, Germany.ORCID 0000-0001-5155-3383
Ulrich DobrindtInstitute of Hygiene, University of Münster, 48149 Münster, Germany. dobrindt@uni-muenster.de.ORCID 0000-0001-9949-1898
Stefan ReuterDepartment of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital Münster, 48149 Münster, Germany. sreuter@uni-muenster.de.ORCID 0000-0002-3011-8347

Funding

Deutsche Forschungsgemeinschaft SFB1009, TP B05, and B10University of Münster, Medical Faculty of the University of Münster Medizinerkolleg MedK
6 · The paper itself

Abstract

Urinary tract infection (UTI), frequently caused by uropathogenic Escherichia coli (UPEC), is the most common infection after kidney transplantation (KTx). Untreated, it can lead to urosepsis and impairment of the graft function. We questioned whether the UPEC isolated from KTx patients differed from the UPEC of non-KTx patients. Therefore, we determined the genome sequences of 182 UPEC isolates from KTx and control patients in a large German university clinic and pheno- and genotypically compared these two isolated groups. Resistance to the β-lactams, trimethoprim or trimethoprim/sulfamethoxazole was significantly higher among UPEC from KTx than from control patients, whereas both the isolated groups were highly susceptible to fosfomycin. Accordingly, the gene content conferring resistance to β-lactams or trimethoprim, but also to aminoglycosides, was significantly higher in KTx than in control UPEC isolates.

Indexed as

antibiotic resistancegenomicskidney transplantationphylogenyUPECUropathogenic E. colivirulence traits

Identifiers

PMID31284699
PMCPMC6678207

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.