Evidence map›Paper›PMID 31284615›Full record

ArticleNanomaterials (Basel, Switzerland)2019

Comparative in Vitro Cytotoxicity of Realistic Doses of Benchmark Multi-Walled Carbon Nanotubes towards Macrophages and Airway Epithelial Cells.

Luisana Di Cristo, Massimiliano G Bianchi, Martina Chiu, Giuseppe Taurino, Francesca Donato, Giacomo Garzaro, Ovidio Bussolati, Enrico Bergamaschi

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  9. Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers.International journal of nanomedicine · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Luisana Di CristoLaboratory of General Pathology, Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy.
Massimiliano G BianchiLaboratory of General Pathology, Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy.
Martina ChiuLaboratory of General Pathology, Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy.
Giuseppe TaurinoLaboratory of General Pathology, Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy.
Francesca DonatoDepartment of Public Health Sciences and Pediatrics, University of Turin, 10126 Turin, Italy.
Giacomo GarzaroDepartment of Public Health Sciences and Pediatrics, University of Turin, 10126 Turin, Italy.
Ovidio BussolatiLaboratory of General Pathology, Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy. ovidio.bussolati@unipr.it.
Enrico BergamaschiDepartment of Public Health Sciences and Pediatrics, University of Turin, 10126 Turin, Italy. enrico.bergamaschi@unito.it.
University of Parma · ITUniversity of Turin · IT

Funding

Horizon 2020 Framework Programme NMBP n. 760928Seventh Framework Programme NMP4-LA-2011-26321
6 · The paper itself

Abstract

Multi-walled carbon nanotubes (MWCNT) have many outstanding physical and chemical properties that make them useful in many applications in nanotechnology. However, these properties are reported to be potentially harmful for the human body. The effects of low and realistic doses of three well-characterized preparations of MWCNT, obtained from the Joint Research Centre (JRC) (NM-400, NM-401, and NM-402), were assessed in two murine macrophage lines, Raw264.7, of peritoneal origin, and MH-S, derived from alveolar macrophages. Macrophage viability, evaluated with two distinct methods, was significantly lowered by NM-401 (needle-like, average length 4 μm, diameter 67 nm) with IC

Indexed as

airway epitheliumbarrier permeabilityinflammationmacrophagesmultiwalled carbon nanotubesrealistic doses

Identifiers

PMID31284615
PMCPMC6669589
OpenAlexW2954560042

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.