Evidence map›Paper›PMID 31284561›Full record

ArticleMolecules (Basel, Switzerland)2019

Evaluating the Anti-cancer Efficacy of a Synthetic Curcumin Analog on Human Melanoma Cells and Its Interaction with Standard Chemotherapeutics.

Krishan Parashar, Siddhartha Sood, Ali Mehaidli, Colin Curran, Caleb Vegh, Christopher Nguyen, Christopher Pignanelli, Jianzhang Wu, Guang Liang, Yi Wang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Krishan ParasharDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, ON N9B 3P4, Canada.ORCID 0000-0001-5706-2446
Siddhartha SoodDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, ON N9B 3P4, Canada.ORCID 0000-0003-3531-5961
Ali MehaidliDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, ON N9B 3P4, Canada.
Colin CurranDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, ON N9B 3P4, Canada.
Caleb VeghDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, ON N9B 3P4, Canada.
Christopher NguyenDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, ON N9B 3P4, Canada.
Christopher PignanelliDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, ON N9B 3P4, Canada.
Jianzhang WuChemical Biology Research Center, School of Pharmaceutical Sciences, Whenzhou Medical University, University Town, Chashan, Wenzhou 325035, China.
Guang LiangChemical Biology Research Center, School of Pharmaceutical Sciences, Whenzhou Medical University, University Town, Chashan, Wenzhou 325035, China.
Yi WangChemical Biology Research Center, School of Pharmaceutical Sciences, Whenzhou Medical University, University Town, Chashan, Wenzhou 325035, China.
Siyaram PandeyDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, ON N9B 3P4, Canada. spandey@uwindsor.ca.ORCID 0000-0002-7273-7154
University of Windsor · CAWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanoma is the leading cause of skin-cancer related deaths in North America. Metastatic melanoma is difficult to treat and chemotherapies have limited success. Furthermore, chemotherapies lead to toxic side effects due to nonselective targeting of normal cells. Curcumin is a natural product of

Indexed as

Drug InteractionsAntineoplastic Agents, PhytogenicApoptosisCell Line, TumorCell SurvivalCisplatinCurcuminDose-Response Relationship, DrugHumansMelanomaMitochondriaMolecular StructureOxidative StressPaclitaxelTamoxifenAntineoplastic Agents, PhytogenicCisplatinCurcuminPaclitaxelTamoxifenapoptosiscisplatincurcumin analogdrug–drug interactionmelanomaoxidative stresstamoxifentaxol

Identifiers

PMID31284561
PMCPMC6651075
OpenAlexW2955589866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.