Evidence map›Paper›PMID 31284541›Full record

ArticleInternational journal of molecular sciences2019

Insulin Treatment Forces Arteriogenesis in Diabetes Mellitus by Upregulation of the Early Growth Response-1 (Egr-1) Pathway in Mice.

Senthilkumar Thulasingam, Sundar Krishnasamy, David Raj C, Manuel Lasch, Srinivasan Vedantham, Elisabeth Deindl

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. P2YBiomedicines · 2025
    Article
  3. Article
  4. From Increased Fluid Shear Stress to Natural Bypass Growth.International journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Senthilkumar ThulasingamSchool of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur 613401, India.
Sundar KrishnasamySchool of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur 613401, India.ORCID 0000-0002-9382-1814
David Raj CSchool of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur 613401, India.ORCID 0000-0003-1187-2595
Manuel LaschDepartment of Otorhinolaryngology, Head & Neck Surgery, University Hospital, LMU Munich, 81377 Munich, Germany.
Srinivasan VedanthamSchool of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur 613401, India.
Elisabeth DeindlWalter-Brendel-Centre of Experimental Medicine, University Hospital, LMU Munich, 81377 Munich, Germany. Elisabeth.Deindl@med.uni-muenchen.de.ORCID 0000-0002-2134-0966
SASTRA University · INLMU Klinikum · DELudwig-Maximilians-Universität München · DE

Funding

ICMR-BMBF [50/6/2013/BMS]
6 · The paper itself

Abstract

The process of arteriogenesis is severely compromised in patients with diabetes mellitus (DM). Earlier studies have reported the importance of

Indexed as

Signal TransductionAnimalsAntigens, CDCollateral CirculationDiabetes Mellitus, ExperimentalEarly Growth Response Protein 1Femoral ArteryGene Expression RegulationInsulinsLeukocytesMaleMice, Inbred C57BLMorphogenesisRNA, MessengerUp-RegulationAntigens, CDEarly Growth Response Protein 1InsulinsRNA, Messengerarteriogenesiscollateral arteriesdiabetes mellitusEgr-1endothelial cellsinsulinsmooth muscle cellsstreptozotocin

Identifiers

PMID31284541
PMCPMC6651530
OpenAlexW2954872336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.