Evidence map›Paper›PMID 31284372›Full record

ReviewCancers2019

Systematic Review and Meta-Analysis of Randomized, Controlled Trials on Preoperative Physical Exercise Interventions in Patients with Non-Small-Cell Lung Cancer.

Ilem D Rosero, Robinson Ramírez-Vélez, Alejando Lucia, Nicolas Martínez-Velilla, Alejandro Santos-Lozano, Pedro L Valenzuela, Idoia Morilla, Mikel Izquierdo

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 67 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06732193 narecruitingnot on this mapstarted 2025, after this paper: background citation

Clinical Trial Comparing a Face-to-face Perioperative Respiratory Physiotherapy Program Versus the Use of Fissios App© as a Complement to a Respiratory Physiotherapy Program in Patients Diagnosed With NSCLC Undergoing Surgery.

TypeinterventionalSponsorCarlos Alfredo Fraile Olivero, MD, PhD.Ran2025 to 2026Enrolled560ConditionsSurgical Procedure, Unspecified, Non Small Cell Lung Cancer, Surgery Scheduled, Thoracic SurgeryArmsOn-site respiratory physiotherapy, Fissios App
NCT07216209 narecruitingnot on this mapstarted 2026, after this paper: background citation

Exercise and the Lung Cancer Tumor Microenvironment

TypeinterventionalSponsorUniversity of ArizonaRan2026 to 2030Enrolled48ConditionsLung Cancer - Non Small CellArmsEXERCISE TRAINING WITH OR WITHOUT MEDICATION
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  5. The use of respiratory muscle training in patients with pulmonary dysfunction, internal diseases or central nervous system disorders: a systematic review with meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Pooled it
  6. Preoperative exercise training for people with non-small cell lung cancer.The Cochrane database of systematic reviews · 2022
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  11. Exercise prescription for symptoms and quality of life improvements in lung cancer patients: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ilem D RoseroDepartment of Health Sciences, Public University of Navarra, Navarrabiomed-Biomedical Research Centre, IDISNA-Navarra's Health Research Institute, C/irunlarrea 3, Complejo Hospitalario de Navarra, 31008 Pamplona, Navarra, Spain.
Robinson Ramírez-VélezDepartment of Health Sciences, Public University of Navarra, Navarrabiomed-Biomedical Research Centre, IDISNA-Navarra's Health Research Institute, C/irunlarrea 3, Complejo Hospitalario de Navarra, 31008 Pamplona, Navarra, Spain.ORCID 0000-0003-3075-6960
Alejando LuciaResearch Institute of the Hospital 12 de Octubre (i + 12), 28670 Madrid, Spain.
Nicolas Martínez-VelillaDepartment of Health Sciences, Public University of Navarra, Navarrabiomed-Biomedical Research Centre, IDISNA-Navarra's Health Research Institute, C/irunlarrea 3, Complejo Hospitalario de Navarra, 31008 Pamplona, Navarra, Spain.
Alejandro Santos-LozanoResearch Institute of the Hospital 12 de Octubre (i + 12), 28670 Madrid, Spain.ORCID 0000-0002-2309-3583
Pedro L ValenzuelaDepartment of Systems Biology, University of Alcalá, 28805 Madrid, Spain.ORCID 0000-0003-1730-3369
Idoia MorillaDepartment of Health Sciences, Public University of Navarra, Navarrabiomed-Biomedical Research Centre, IDISNA-Navarra's Health Research Institute, C/irunlarrea 3, Complejo Hospitalario de Navarra, 31008 Pamplona, Navarra, Spain.
Mikel IzquierdoDepartment of Health Sciences, Public University of Navarra, Navarrabiomed-Biomedical Research Centre, IDISNA-Navarra's Health Research Institute, C/irunlarrea 3, Complejo Hospitalario de Navarra, 31008 Pamplona, Navarra, Spain. mikel.izquierdo@gmail.com.ORCID 0000-0002-1506-4272

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preoperative physical exercise protocols prior to cancer surgery increased in popularity over recent years; however, the beneficial effect of such protocols is not well established, with conflicting results reported. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effects of different modalities or combinations of preoperative exercise interventions and/or prehabilitation multicomponent training in patients with non-small-cell lung cancer (NSCLC) after surgery on the outcomes related to functional capacity, mental wellness and medical care. We searched in OVID Embase, Pubmed, Cochrane Library, CINAHL, Scopus, and Web of Science. Characteristics of studies and program results and outcome data were extracted. Changes between the intervention and control groups, from baseline to follow-up (standardized mean difference (SMD) or relative risk (RR) with 95% confidence interval (CI) for each intervention was pooled using weighted random-effects models). A total of 676 participants from 10 RCTs were included in the final analysis (aerobic training + inspiratory muscle training,

Indexed as

cardiovascularfunctional capacitylung cancerresistance training

Identifiers

PMID31284372
PMCPMC6678369

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.