Evidence map›Paper›PMID 31284092›Full record

ArticleEnvironment international2019

PFAS health effects database: Protocol for a systematic evidence map.

Katherine E Pelch, Anna Reade, Taylor A M Wolffe, Carol F Kwiatkowski

Abstract read
PubMed Publisher
In one paragraph

Article in Environment international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Determinants of maternal and neonatal PFAS concentrations: a review.Environmental health : a global access science source · 2023
    Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Trends, Dynamicity in Collaboration, and Impact on Perfluorooctanoic Acid and Cancer Research: A Scientometric Study.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Indoor air concentrations of PMEnvironmental science. Processes & impacts · 2025
    Article
  17. Review
  18. Review
  19. Review
  20. Review

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Katherine E PelchThe Endocrine Disruption Exchange, PO Box 54, Eckert, CO, USA. Electronic address: katiepelch@tedx.org.
Anna ReadeHealthy People & Thriving Communities Program, Natural Resources Defense Council, 111 Sutter Street, Floor 21, San Francisco, CA, USA. Electronic address: areade@nrdc.org.
Taylor A M WolffeLancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, UK. Electronic address: t.wolffe@lancaster.ac.uk.
Carol F KwiatkowskiThe Endocrine Disruption Exchange, PO Box 54, Eckert, CO, USA; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA. Electronic address: carolkw@tedx.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPer- and polyfluoroalkyl substances (PFAS) confer waterproof, greaseproof, and non-stick properties when added to consumer products. They are also used for industrial purposes including in aqueous film forming foams for firefighting. PFAS are ubiquitous in the environment, are widely detected in human biomonitoring studies, and are of growing regulatory concern across federal, state, and local governments. Regulators, scientists, and citizens need to stay informed on the growing health and toxicology literature related to PFAS.

objectivesThe goal of this systematic evidence map is to identify and organize the available health and toxicology related literature on a set of 29 PFAS of emerging and growing concern. SEARCH AND STUDY ELIGIBILITY: We will search the electronic database PubMed for health or toxicological studies on 29 PFAS of emerging concern. Eligible studies must contain primary research investigating the link between one or more of the PFAS of interest and a health effect, toxicological, or biological mechanistic endpoint. STUDY APPRAISAL AND SYNTHESIS

methodsTitle and abstract screening and full text review will require a single reviewer for inclusion to the next level and two independent reviewers for exclusion. Study quality will not be conducted for this evidence mapping. Study characteristics will be extracted and coded from the included studies and checked for accuracy by a second reviewer. The extracted and coded information will be visualized in a publicly available, interactive database hosted on Tableau Public. Results of the evidence mapping will be published in a narrative summary.

Indexed as

FluorocarbonsAnimalsDatabases, FactualHealth StatusHumansSystematic Reviews as TopicFluorocarbonsPer- and polyfluoroalkyl substancesPFASSystematic evidence mapToxicology

Identifiers

PMID31284092

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.