Evidence map›Paper›PMID 31283993›Full record

ArticlePapillomavirus research (Amsterdam, Netherlands)2019

Identification by high-throughput sequencing of HPV variants and quasispecies that are untypeable by linear reverse blotting assay in cervical specimens.

Lucie Molet, Delphine Girlich, Rémy A Bonnin, Alexis Proust, Jérôme Bouligand, Françoise Bachelerie, Sébastien Hantz, Claire Deback

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Papillomavirus research (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Lucie MoletLaboratoire de Virologie, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Paris Sud, Hôpital Paul Brousse, Villejuif, France; INSERM UMR-996 « Inflammation, Chimiokines et Immunopathologies », Université Paris Sud, Université Paris Saclay, LabEx Lermit, Faculté de Médecine, Clamart, France.
Delphine GirlichEA7361 « Structure, Dynamics, Function and Expression of Broad-spectrum β-lactamases », Université Paris Sud, Université Paris Saclay, LabEx Lermit, Faculté de Médecine, Le Kremlin-Bicêtre, France.
Rémy A BonninEA7361 « Structure, Dynamics, Function and Expression of Broad-spectrum β-lactamases », Université Paris Sud, Université Paris Saclay, LabEx Lermit, Faculté de Médecine, Le Kremlin-Bicêtre, France.
Alexis ProustLaboratoire de génétique moléculaire, pharmacogénétique et hormonologie, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
Jérôme BouligandLaboratoire de génétique moléculaire, pharmacogénétique et hormonologie, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Bicêtre, Le Kremlin-Bicêtre, France; INSERM UMR-1185 « Signalisation Hormonale, Physiopathologie Endocrinienne et Métabolique », Université Paris Sud, Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France.
Françoise BachelerieINSERM UMR-996 « Inflammation, Chimiokines et Immunopathologies », Université Paris Sud, Université Paris Saclay, LabEx Lermit, Faculté de Médecine, Clamart, France.
Sébastien HantzUniv. Limoges, RESINFIT, U1092, F-87000, Limoges, France; CHU Limoges, Laboratoire de Bactériologie-Virologie-Hygiène, F-87000, Limoges, France.
Claire DebackLaboratoire de Virologie, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Paris Sud, Hôpital Paul Brousse, Villejuif, France; INSERM UMR-996 « Inflammation, Chimiokines et Immunopathologies », Université Paris Sud, Université Paris Saclay, LabEx Lermit, Faculté de Médecine, Clamart, France. Electronic address: claire.deback@aphp.fr.
Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation ThérapeutiqueAssistance Publique – Hôpitaux de Paris · FRBicêtre Hospital · FRCentre Hospitalier Universitaire de Limoges · FRUniversité Paris-Saclay · FRUniversité Paris-Sud · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The linear reverse blotting assays are valid methods for accurate human papillomavirus (HPV) typing required to manage women at risk of developing cervical cancer. However, some samples showed a positive signal in HPV lines but failed to display a positive signal in subsequent typing lines (designated as HPV-X), which indicate that certain types were not available on the respective typing blots. The aim of this study is to elucidate the types or variants of HPV through the high-throughput sequencing (HTS) of 54 ASCUS cervical samples in which the viruses remained untypeable with INNO LiPA HPV

Indexed as

Genetic VariationHigh-Throughput Nucleotide SequencingBase SequenceCervix UteriDNA, ViralFemaleGenotypeHumansMolecular TypingPapillomaviridaePapillomavirus InfectionsPhylogenyQuasispeciesSequence Analysis, DNAUterine Cervical NeoplasmsDNA, ViralGenotypingHigh-throughput sequencingHuman papillomavirusQuasispeciesVariants

Identifiers

PMID31283993
PMCPMC6620621
OpenAlexW2953785537

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.