ArticleGenes, brain, and behavior2020
Heterozygous loss of epilepsy gene KCNQ2 alters social, repetitive and exploratory behaviors.
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Article in Genes, brain, and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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0cells of the map it votes in
27citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
What it found
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Who cites it
27 citing papers in PubMed, 31 citations in OpenAlex.
- Hyperfunction of PSD-95 leads to hyperexcitability and cognitive abnormalities in MEF2C haploinsufficiency.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Temporal multi-omic exploration of the ventral tegmental area in chronic pain and passive coping behaviors.iScience · 2026Article
- Increased alcohol drinking and seizure susceptibility in female humanized ApoE4 knockin rats.Physiology & behavior · 2026Article
- R-loop landscapes in the developing human brain are linked to neural differentiation and cell type-specific transcription.Translational psychiatry · 2026Article
- Kcnq2 R213 knock-in mice reveal variant- and region-specific mechanisms underlying self-limited familial neonatal-infantile epilepsy and early infantile developmental and epileptic encephalopathy.Acta neuropathologica communications · 2026Article
- Postnatal reduction of eIF4E overexpression in D1-SPNs ameliorates KCNQ channel dysfunction, hyperexcitability and ASD-like behaviours.Cellular and molecular life sciences : CMLS · 2026Article
- Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes.Nature reviews. Neurology · 2024Review
- An allelic series of spontaneous Rorb mutant mice exhibit a gait phenotype, changes in retina morphology and behavior, and gene expression signatures associated with the unfolded protein response.G3 (Bethesda, Md.) · 2023Article
- Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.Nature communications · 2023Article
- Proteomic-Based Approach Reveals the Involvement of Apolipoprotein A-I in Related Phenotypes of Autism Spectrum Disorder in the BTBR Mouse Model.International journal of molecular sciences · 2022Article
- Mouse models of Kcnq2 dysfunction.Epilepsia · 2022Review
- Autism Spectrum Disorder and a De Novo Kcnq2 Gene Mutation: A Case Report.Pediatric reports · 2022Article
- KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Heterozygous Deletion of Epilepsy GeneFrontiers in behavioral neuroscience · 2022Article
- Clinical Study of 30 NovelFrontiers in molecular neuroscience · 2022Article
- Spontaneous seizure and memory loss in mice expressing an epileptic encephalopathy variant in the calmodulin-binding domain of KProceedings of the National Academy of Sciences of the United States of America · 2021Article
- PIPCommunications biology · 2021Article
- Kv7 Channels and Excitability Disorders.Handbook of experimental pharmacology · 2021Article
- KCNQ2 encephalopathy manifesting with Rett-like features: A follow-up into adulthood.Neurology. Genetics · 2020Article
- Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies.Pharmacological reviews · 2020Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Eung Chang KimDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Jaimin PatelDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Jiaren ZhangDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Heun SohDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut.
Justin S RhodesBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Anastasios V TzingounisDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut.
Hee Jung ChungDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois.ORCID 0000-0002-5555-9907
University of Illinois Urbana-Champaign · USUniversity of Connecticut · US
Funding
Role of KCNQ2 Channels in Control of BreathingR01HL137094 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K, TZINGOUNIS, ANASTASIOS · 2018 to 2025
$4.1MKCNQ2/3 channels and interneuron physiologyR01NS101596 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI TZINGOUNIS, ANASTASIOS · 2017 to 2021
$1.7MTuning neuronal excitability by axonal targeting of Kv7 channelsR01NS083402 · NINDS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHUNG, HEE JUNG · 2015 to 2019
$1.7MOrigins of exercise-brain interactionsR21NS104293 · NINDS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BOPPART, MARNI D., RHODES, JUSTIN S · 2018 to 2019
$403kNHLBI NIH HHS HL137094NHLBI NIH HHS R01 HL137094NINDS NIH HHS NS101596NINDS NIH HHS NS104293NINDS NIH HHS NS10887NINDS NIH HHS R01 NS083402NINDS NIH HHS R01 NS101596NINDS NIH HHS R21 NS104293
Abstract
KCNQ/K
Indexed as
Exploratory BehaviorGroomingLoss of Function MutationSocial BehaviorAnimalsFemaleHeterozygoteKCNQ2 Potassium ChannelMaleMiceMice, Inbred C57BLNerve Tissue ProteinsStereotyped BehaviorKCNQ2 Potassium ChannelKcnq2 protein, mouseNerve Tissue ProteinsanxietyepilepsyexcitabilityKCNQ2Kv7 channelslocomotionseizuressocial dominancesocial interaction
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.