Evidence map›Paper›PMID 31283794›Full record

ArticlePloS one2019

High risk for latent tuberculosis infection among medical residents and nursing students in India.

Aarti Kinikar, Ajay Chandanwale, Dileep Kadam, Samir Joshi, Anita Basavaraj, Geeta Pardeshi, Sunita Girish, Sangeeta Shelke, Andrea DeLuca, Gauri Dhumal and 6 more

Abstract read
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Latent tuberculosis infection in medical students in the Northeast of Mexico.Journal of clinical tuberculosis and other mycobacterial diseases · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Prevalence of Tuberculosis Infection among Adults of Thiruvananthapuram District of Kerala as Measured by Interferon Gamma Release Assay - A Cross-Sectional Study.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
    Article
  18. Article
  19. Prevalence of Tuberculosis Infection among Various Risk Groups in India: A Systematic Review and Meta-Analysis.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Aarti KinikarDepartment of Pediatrics, BJGMC-JHU Clinical Trial Unit, Byramjee-Jeejeebhoy Government Medical College, Pune, Maharashtra, India.ORCID 0000-0001-9466-1130
Ajay ChandanwaleDepartment of Orthopedics, BJGMC-JHU Clinical Trial Unit, Byramjee-Jeejeebhoy Government Medical College, Pune, Maharashtra, India.
Dileep KadamDepartment of Medicine, Smt. Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India.
Samir JoshiDepartment of ENT, BJGMC-JHU Clinical Trial Unit, Byramjee-Jeejeebhoy Government Medical College, Pune, Maharashtra, India.
Anita BasavarajDepartment of Medicine, Government Medical College, Miraj, Maharashtra, India.
Geeta PardeshiDepartment of Community Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
Sunita GirishDepartment of Biochemistry, BJGMC-JHU Clinical Trial Unit, Byramjee-Jeejeebhoy Government Medical College, Pune, Maharashtra, India.
Sangeeta ShelkeDepartment of Community Medicine, BJGMC-JHU Clinical Trial Unit, Byramjee-Jeejeebhoy Government Medical College, Pune, Maharashtra, India.
Andrea DeLucaDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States of America.
Gauri DhumalBJGMC-JHU Clinical Trial Unit, Byramjee-Jeejeebhoy Government Medical College, Pune, Maharashtra, India.
Jonathan GolubDepartment of Medicine, Epidemiology and International Health, Johns Hopkins University School of Medicine and the Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Nilima LokhandeBJGMC-JHU Clinical Trial Unit, Byramjee-Jeejeebhoy Government Medical College, Pune, Maharashtra, India.
Nikhil GupteBJGMC-JHU Clinical Trial Unit, Byramjee-Jeejeebhoy Government Medical College, Pune, Maharashtra, India.
Amita GuptaDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Robert BollingerDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Vidya MaveBJGMC-JHU Clinical Trial Unit, Byramjee-Jeejeebhoy Government Medical College, Pune, Maharashtra, India.

Funding

Johns Hopkins AIDS Clinical Trials UnitU01AI069465 · NIAID · JOHNS HOPKINS UNIVERSITY · PI FLEXNER, CHARLES W. · 2007 to 2011
$7.9M
HIV-TB Fogarty Research Training ProgramD43TW009574 · FIC · JOHNS HOPKINS UNIVERSITY · PI BOLLINGER, ROBERT C. · 2013 to 2017
$1.0M
FIC NIH HHS D43 TW009574NIAID NIH HHS U01 AI069465
6 · The paper itself

Abstract

Defining occupational latent tuberculosis infection (LTBI) risk among healthcare workers is needed to support implementation of prevention guidelines. Prospective cohort study of 200 medical residents and nursing students in India was conducted May 2016-December 2017. Tuberculin skin test (TST) and QuantiFERON TB Gold Test-in-tube (QFT-GIT) were performed at study entry and 12 months. Primary outcome was incident LTBI (≥10mm TST induration and/or ≥0.35IU/mL QFT-GIT) at 12 months; secondary outcomes included baseline LTBI prevalence and risk factors for incident and prevalent LTBI using Poisson regression. Among 200, [90 nursing students and 110 medical residents], LTBI prevalence was 30% (95% CI, 24-37); LTBI incidence was 26.8 (95% CI, 18.6-37.2) cases per 100 person-years and differed by testing method (28.7 [95% CI, 20.6-38.9] vs 17.4 [95% CI, 11.5-25.4] cases per 100 person-years using TST and QFT-GIT, respectively). Medical residents had two-fold greater risk of incident LTBI than nursing students (Relative Risk, 2.16; 95% CI, 1.05-4.42). During study period 6 (3%) HCWs were diagnosed with active TB disease. Overall, median number of self-reported TB exposures was 5 (Interquartile Range, 1-15). Of 60 participants with prevalent and incident LTBI who were offered free isoniazid preventive therapy (IPT), only 2 participants initiated and completed IPT. High risk for LTBI was noted among medical residents compared to nursing students. Self-reported TB exposure is underreported, and uptake of LTBI prevention therapy remains low. New approaches are needed to identify HCWs at highest risk for LTBI.

Indexed as

Internship and ResidencyStudents, NursingAdultAntitubercular AgentsCohort StudiesFemaleHumansIncidenceIndiaInterferon-gamma Release TestsIsoniazidLatent TuberculosisLongitudinal StudiesMaleOccupational DiseasesOccupational ExposureAntitubercular AgentsIsoniazid

Identifiers

PMID31283794
PMCPMC6613683

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.