Evidence map›Paper›PMID 31283683›Full record

ArticleTransplantation2020

Gender Disparities in Patients With Alcoholic Liver Disease Evaluated for Liver Transplantation.

Lisa M McElroy, Alisa Likhitsup, Gerald Scott Winder, Naba Saeed, Ammar Hassan, Christopher J Sonnenday, Robert J Fontana, Jessica Mellinger

Open access · greenAbstract read
In one paragraph

Article in Transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 51 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Gender disparity in access to early liver transplant among patients with alcohol associated liver disease and limited sobriety is mediated by psychosocial factors.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026
    Article
  5. Access to early liver transplantation is adversely impacted by social determinants of health: A retrospective cohort study.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2025
    Article
  6. Insights Into Liver Transplant Disparities.Gastroenterology & hepatology · 2025
    Article
  7. Article
  8. Gene-based therapies for steatotic liver disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Current status of disparity in liver disease.World journal of hepatology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lisa M McElroyDepartment of Surgery, University of Michigan, Ann Arbor, MI.
Alisa LikhitsupDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI.
Gerald Scott WinderDepartment of Surgery, University of Michigan, Ann Arbor, MI.
Naba SaeedDepartment of Internal Medicine, Beaumont Hospital, Dearborn, MI.
Ammar HassanDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI.
Christopher J SonnendayDepartment of Surgery, University of Michigan, Ann Arbor, MI.
Robert J FontanaDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI.
Jessica MellingerDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI.
University of Michigan–Ann Arbor · USBeaumont Hospital, Royal Oak · US

Funding

Improving Outcomes in Alcoholic Liver Disease: Integrating Behavioral Interventions into the Hepatology ClinicK23AA026333 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MELLINGER, JESSICA LEIGH · 2018 to 2022
$972k
NIAAA NIH HHS K23 AA026333
6 · The paper itself

Abstract

backgroundThe morbidity and mortality from alcohol-related liver disease (ALD) is increasing in the United States. However, little is known about gender differences in evaluation and listing for liver transplantation (LT) in patients with ALD.

methodsThis is a retrospective review of adult patients with ALD evaluated for LT at a single transplant center from January 1, 2010, to March 1, 2017. Univariate, multivariate, and time-series analyses were performed.

resultsAmong the 949 patients with ALD evaluated, mean age was 53 years, 84% were Caucasian, and 33% were women. The median model for end-stage liver disease score was similar between the genders. Women were less likely to be listed for LT (10% versus 19%; P < 0.05). The proportion of women not listed due to active substance use was significantly higher versus men (42% versus 35%; P < 0.05), while the frequency of medical contraindications was comparable between the genders. During a median follow-up of 416 days (range: 0-2784), listed women with ALD were less likely to undergo transplantation (42% versus 47%; P < 0.05).

conclusionsMen with ALD were 95% more likely to be listed and 105% more likely to be transplanted compared to women with ALD. While men had more lifetime substance use and related consequences, women had more psychiatric comorbidities and were less likely to be listed due to active alcohol and opioid use. Early detection and effective treatment of psychiatric and substance use disorders in women with ALD may improve their transplant eligibility.

Indexed as

FemaleFollow-Up StudiesHumansLiver Diseases, AlcoholicLiver TransplantationMaleMiddle AgedMorbidityPrognosisRetrospective StudiesRisk FactorsSex DistributionSex FactorsSurvival RateTransplant RecipientsUnited States

Identifiers

PMID31283683
PMCPMC8173276
OpenAlexW2960274998

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.