Evidence map›Paper›PMID 31283497›Full record

ArticleIEEE transactions on medical imaging2020

Kinetic Modeling of Hyperpolarized Carbon-13 Pyruvate Metabolism in the Human Brain.

Daniele Mammoli, Jeremy Gordon, Adam Autry, Peder E Z Larson, Yan Li, Hsin-Yu Chen, Brian Chung, Peter Shin, Mark Van Criekinge, Lucas Carvajal and 6 more

Open access · greenAbstract read
In one paragraph

Article in IEEE transactions on medical imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Article
  3. Increasing Infusion Times of Hyperpolarized [1-Magnetic resonance in medicine · 2026
    Article
  4. Clinical Translation of HyperpolarizedAJNR. American journal of neuroradiology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Spatial distribution of hyperpolarized [1-Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  9. Article
  10. A pharmacokinetic model for hyperpolarizedMagnetic resonance in medicine · 2024
    Article
  11. Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024
    Review
  12. DynamicMagnetic resonance in medicine · 2024
    Article
  13. Article
  14. Review
  15. Hyperpolarized [2-NeuroImage · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Structural and functional imaging of brains.Science China. Chemistry · 2023
    Review
  20. Kinetic analysis of multi-resolution hyperpolarizedMagnetic resonance in medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Daniele Mammoli
Jeremy Gordon
Adam Autry
Peder E Z Larson
Yan Li
Hsin-Yu Chen
Brian Chung
Peter Shin
Mark Van Criekinge
Lucas Carvajal
James B Slater
Robert Bok
Jason Crane
Duan Xu
Susan Chang
Daniel B Vigneron
University of California, San Francisco · USNeurological Surgery · US

Funding

Project 4: Multi-modality Metabolic Imaging for Monitoring Molecular Sub-types of GliomaP01CA118816 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Pavithra Viswanath · 2007 to 2026
$44.7M
TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
Development and Translation of Hyperpolarized C-13 Prostate Cancer MRI MethodsR01EB017449 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2013 to 2017
$5.9M
NCI NIH HHS P01 CA118816NCI NIH HHS T32 CA151022NIBIB NIH HHS P41 EB013598NIBIB NIH HHS R01 EB017449
6 · The paper itself

Abstract

Kinetic modeling of the in vivo pyruvate-to-lactate conversion is crucial to investigating aberrant cancer metabolism that demonstrates Warburg effect modifications. Non-invasive detection of alterations to metabolic flux might offer prognostic value and improve the monitoring of response to treatment. In this clinical research project, hyperpolarized [1-

Indexed as

BrainBrain NeoplasmsPyruvic AcidCarbon IsotopesEcho-Planar ImagingHumansImage Interpretation, Computer-AssistedKineticsLactic AcidCarbon-13Carbon IsotopesLactic AcidPyruvic Acid

Identifiers

PMID31283497
PMCPMC6939147
OpenAlexW2955499001

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.