Evidence map›Paper›PMID 31283440›Full record

ReviewAnnual review of virology2019

In Vivo Imaging-Driven Approaches to Study Virus Dissemination and Pathogenesis.

Pradeep D Uchil, Kelsey A Haugh, Ruoxi Pi, Walther Mothes

Abstract readReview
In one paragraph

Review in Annual review of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
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  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pradeep D UchilDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06510, USA; email: pradeep.uchil@yale.edu, kelsey.haugh@yale.edu, ruoxi.pi@yale.edu, walther.mothes@yale.edu.
Kelsey A HaughDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06510, USA; email: pradeep.uchil@yale.edu, kelsey.haugh@yale.edu, ruoxi.pi@yale.edu, walther.mothes@yale.edu.
Ruoxi PiDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06510, USA; email: pradeep.uchil@yale.edu, kelsey.haugh@yale.edu, ruoxi.pi@yale.edu, walther.mothes@yale.edu.
Walther MothesDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06510, USA; email: pradeep.uchil@yale.edu, kelsey.haugh@yale.edu, ruoxi.pi@yale.edu, walther.mothes@yale.edu.

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0M
X-ray Cryst. CoreP50GM082545 · NIGMS · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2007 to 2018
$51.1M
Virus TransmissionP50AI150464 · NIAID · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2019 to 2021
$14.9M
Retrovirus cell-to-cell transmissionR01CA098727 · NCI · YALE UNIVERSITY · PI MOTHES, WALTHER H · 2003 to 2017
$4.5M
Predoctoral Training Program in VirologyT32AI055403 · NIAID · YALE UNIVERSITY · PI KUMAR, PRITI, MOTHES, WALTHER H · 2003 to 2024
$3.6M
A super-resolution microscope for research and educationS10OD020142 · OD · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2015 to 2015
$600k
NCI NIH HHS P30 CA016359NCI NIH HHS R01 CA098727NIAID NIH HHS P50 AI150464NIAID NIH HHS T32 AI055403NIGMS NIH HHS P50 GM082545NIH HHS S10 OD020142
6 · The paper itself

Abstract

Viruses are causative agents for many diseases and infect all living organisms on the planet. Development of effective therapies has relied on our ability to isolate and culture viruses in vitro, allowing mechanistic studies and strategic interventions. While this reductionist approach is necessary, testing the relevance of in vitro findings often takes a very long time. New developments in imaging technologies are transforming our experimental approach where viral pathogenesis can be studied in vivo at multiple spatial and temporal resolutions. Here, we outline a vision of a top-down approach using noninvasive whole-body imaging as a guide for in-depth characterization of key tissues, physiologically relevant cell types, and pathways of spread to elucidate mechanisms of virus spread and pathogenesis. Tool development toward imaging of infectious diseases is expected to transform clinical diagnosis and treatment.

Indexed as

Virus Physiological PhenomenaAnimalsDiagnostic ImagingDisease Models, AnimalHumansVirus DiseasesVirusesVirus Replicationimmune responsenoninvasive imagingvirus disseminationvirus infection

Identifiers

PMID31283440
PMCPMC7217087

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.