Evidence map›Paper›PMID 31283012›Full record

ArticleJournal of medical virology2019

Validity of administrative database detection of previously resolved hepatitis B virus in Japan.

Shinobu Imai, Hayato Yamana, Norihiko Inoue, Manabu Akazawa, Hiromasa Horiguchi, Kiyohide Fushimi, Kiyoshi Migita, Hiroshi Yatsuhashi, Masaya Sugiyama, Masashi Mizokami

Open access · hybridAbstract read
In one paragraph

Article in Journal of medical virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Shinobu ImaiDepartment of Clinical Data Management and Research, Clinical Research Center, National Hospital Organization Headquarters, Tokyo, Japan.ORCID 0000-0003-1784-5133
Hayato YamanaDepartment of Clinical Data Management and Research, Clinical Research Center, National Hospital Organization Headquarters, Tokyo, Japan.
Norihiko InoueDepartment of Clinical Data Management and Research, Clinical Research Center, National Hospital Organization Headquarters, Tokyo, Japan.ORCID 0000-0001-9187-371X
Manabu AkazawaDepartment of Public Health and Epidemiology, Meiji Pharmaceutical University, Tokyo, Japan.
Hiromasa HoriguchiDepartment of Clinical Data Management and Research, Clinical Research Center, National Hospital Organization Headquarters, Tokyo, Japan.
Kiyohide FushimiDepartment of Clinical Data Management and Research, Clinical Research Center, National Hospital Organization Headquarters, Tokyo, Japan.
Kiyoshi MigitaDepartment of Rheumatology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Hiroshi YatsuhashiNational Hospital Organization, Nagasaki Medical Center, Omura, Japan.
Masaya SugiyamaThe Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan.
Masashi MizokamiThe Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan.
National Center for Global Health and Medicine · JPNational Hospital Organization · JPTokyo Medical and Dental University · JPFukushima Medical University · JPMeiji Pharmaceutical University · JPNagasaki Medical Center · JPTokyo University of Pharmacy and Life Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The risk of hepatitis B virus (HBV) reactivation has increased owing to advances in the immunosuppressive therapy field. However, the HBV reactivation incidence among patients with previously resolved HBV (prHBV) infection during immunosuppressive therapy for rheumatoid arthritis (RA) remains unclear. The objective of this work is to describe the validity of detecting prHBV infection from administrative data through comparisons with chart abstraction and determine the incidence of HBV reactivation during immunosuppressive therapy for RA in Japan. In this retrospective cohort study, data on selected patients were extracted from administrative claims data. To identify patients with prHBV infection and de novo hepatitis, and HBsAg carriers, we conducted chart abstraction. The incidence rate of de novo hepatitis was 1.23 of 100 person-years. The positive predictive value (PPV) and its 95% confidence interval (CI) of administrative data for the identification of suspected prHBV infections was 85.8% (95% CI: 81.7%-89.3%). This study evaluated the PPV of the algorithm of HBV-DNA testing with immunosuppressive therapy performed four times or more per year for the detection of prHBV infection from administrative data. Additionally, we determined the incidence rate of HBV reactivation among preHBV infections during immunosuppressive therapy for RA to be 1.23 of 100 person-years.

Indexed as

Databases, FactualVirus ActivationAgedAlgorithmsArthritis, RheumatoidBiostatisticsFemaleHepatitis BHepatitis B virusHumansImmunosuppression TherapyImmunosuppressive AgentsIncidenceJapanMaleMiddle AgedImmunosuppressive Agentsbiostatistics and bioinformaticschemotherapydisease controlhepatitis B virusinfectionreactivation

Identifiers

PMID31283012
PMCPMC6771469
OpenAlexW2957152953

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.