Evidence map›Paper›PMID 31282864›Full record

ArticleeLife2019

Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome.

Kevin M Goff, Ethan M Goldberg

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 103 citations in OpenAlex.

  1. Article
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  6. Review
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  8. Review
  9. Article
  10. Ndnf Interneuron Excitability Is Spared in a Mouse Model of Dravet Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  11. Article
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  15. Article
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  17. eLife · 2023
    Article
  18. Mechanisms of Dominant Electrophysiological Features of Four Subtypes of Layer 1 Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  19. Article
  20. Involvement of GABAergic Interneuron Subtypes in 4-Aminopyridine-Induced Seizure-Like Events in Mouse Entorhinal CortexThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kevin M GoffDepartment of Neuroscience, The University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.ORCID 0000-0001-5862-0219
Ethan M GoldbergDepartment of Neuroscience, The University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.ORCID 0000-0002-7404-735X
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Interneuron axonopathy underlies circuit dysfunction in a mouse model of Dravet syndromeR01NS110869 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI ETHAN M GOLDBERG · 2019 to 2026
$3.5M
Dynamic two-photon calcium imaging and optogenetic manipulation of epileptic brain circuits in an experimental model of temporal lobe epilepsyK08NS097633 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI GOLDBERG, ETHAN M · 2016 to 2020
$921k
Identifying a Role for Vasoactive Intestinal Peptide Expressing Interneurons in a Mouse Model of Dravet SyndromeF31NS111803 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI GOFF, KEVIN · 2019 to 2021
$83k
Burroughs Wellcome Fund Career Award for Medical ScientistsNINDS NIH HHS F31 NS111803NINDS NIH HHS K08 NS097633NINDS NIH HHS R01 NS110869
6 · The paper itself

Abstract

Dravet Syndrome (DS) is a severe neurodevelopmental disorder caused by pathogenic loss of function variants in the gene

Indexed as

Action PotentialsAnimalsBrainEpilepsies, MyoclonicInterneuronsMice, 129 StrainMice, Inbred C57BLMice, KnockoutMice, TransgenicNAV1.1 Voltage-Gated Sodium ChannelVasoactive Intestinal PeptideNAV1.1 Voltage-Gated Sodium ChannelScn1a protein, mouseVasoactive Intestinal Peptideelectrophysiologyepilepsyion channelsmouseNav1.1neuroscienceSCN1A

Identifiers

PMID31282864
PMCPMC6629374
OpenAlexW2958569275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.