ArticleeLife2019
Network-wide abnormalities explain memory variability in hippocampal amnesia.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Brain functional basis of the association between positive expectation and acupuncture efficacy in knee osteoarthritis.Brain imaging and behavior · 2026Trial
- Toward reliable thalamic segmentation: an evaluation of automated methods for structural MRI.Brain structure & function · 2026Article
- Structural MRI across lifespan reveals differential thalamic trajectories in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Diencephalic integrity explains aspects of hippocampal amnesia.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- What episodic memory reveals about the default mode network.Current opinion in behavioral sciences · 2026Article
- Despite dense amnesia, patients with hippocampal lesions show partially intact navigation for recent and remotely learned environments.Neuropsychologia · 2025Article
- Cognitive Deficits in Anti-LGI1 Encephalitis Are Linked to Immunotherapy-Resistant White Matter Network Changes.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Hippocampal damage disrupts the latent decision-making processes underlying approach-avoidance conflict processing in humans.PLoS biology · 2025Article
- Visual imagery of familiar people and places in category selective cortex.Neuroscience of consciousness · 2025Article
- The Impact of Ageing on Episodic Memory Retrieval: How Valence Influences Neural Functional Connectivity.NeuroSci · 2024Article
- The role of the human hippocampus in decision-making under uncertainty.Nature human behaviour · 2024Article
- Differential effects of bilateral hippocampal CA3 damage on the implicit learning and recognition of complex event sequences.Cognitive neuroscience · 2024Article
- Mesiotemporal Volumetry, Cortical Thickness, and Neuropsychological Deficits in the Long-term Course of Limbic Encephalitis.Neurology(R) neuroimmunology & neuroinflammation · 2023Article
- Spatial navigation and memory: A review of the similarities and differences relevant to brain models and age.Neuron · 2023Review
- Brain-wide connectome inferences using functional connectivity MultiVariate Pattern Analyses (fc-MVPA).PLoS computational biology · 2022Article
- Functional Specialization of the Medial Temporal Lobes in Human Recognition Memory: Dissociating Effects of Hippocampal versus Parahippocampal Damage.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Relationships Between Memory Impairments and Hippocampal Structure in Patients With Subcortical Ischemic Vascular Disease.Frontiers in aging neuroscience · 2022Article
- Hippocampal volume and navigational ability: The map(ping) is not to scale.Neuroscience and biobehavioral reviews · 2021Review
- Amnesia for context fear is caused by widespread disruption of hippocampal activity.Neurobiology of learning and memory · 2020Article
- Category Selectivity for Face and Scene Recognition in Human Medial Parietal Cortex.Current biology : CB · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Patients with hippocampal amnesia play a central role in memory neuroscience but the neural underpinnings of amnesia are hotly debated. We hypothesized that focal hippocampal damage is associated with changes across the extended hippocampal system and that these, rather than hippocampal atrophy per se, would explain variability in memory between patients. We assessed this hypothesis in a uniquely large cohort of patients (n = 38) after autoimmune limbic encephalitis, a syndrome associated with focal structural hippocampal pathology. These patients showed impaired recall, recognition and maintenance of new information, and remote autobiographical amnesia. Besides hippocampal atrophy, we observed correlatively reduced thalamic and entorhinal cortical volume, resting-state inter-hippocampal connectivity and activity in posteromedial cortex. Associations of hippocampal volume with recall, recognition, and remote memory were fully mediated by wider network abnormalities, and were only direct in forgetting. Network abnormalities may explain the variability across studies of amnesia and speak to debates in memory neuroscience.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.