Evidence map›Paper›PMID 31282860›Full record

ArticleeLife2019

Large protein organelles form a new iron sequestration system with high storage capacity.

Tobias W Giessen, Benjamin J Orlando, Andrew A Verdegaal, Melissa G Chambers, Jules Gardener, David C Bell, Gabriel Birrane, Maofu Liao, Pamela A Silver

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 165 citations in OpenAlex.

  1. Article
  2. Buffer and salt dependent reassembly pathways of Myxococcus xanthus encapsulin.Protein science : a publication of the Protein Society · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Chemical reviews · 2026
    Review
  8. Article
  9. Review
  10. Article
  11. Characterization of Iron Oxide Nanoparticles Inside theNanomaterials (Basel, Switzerland) · 2025
    Article
  12. Article
  13. Article
  14. Engineering Spatial Control of Bacterial Organelles.bioRxiv : the preprint server for biology · 2025
    Article
  15. Review
  16. Article
  17. Encapsulins: catalysis inside a shell.Current opinion in microbiology · 2025
    Review
  18. Article
  19. Article
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Tobias W GiessenDepartment of Systems Biology, Harvard Medical School, Boston, United States.ORCID 0000-0001-6328-2031
Benjamin J OrlandoDepartment of Cell Biology, Harvard Medical School, Boston, United States.
Andrew A VerdegaalDepartment of Systems Biology, Harvard Medical School, Boston, United States.ORCID 0000-0002-4517-6961
Melissa G ChambersDepartment of Cell Biology, Harvard Medical School, Boston, United States.ORCID 0000-0001-5111-7194
Jules GardenerCenter for Nanoscale Systems, Harvard University, Cambridge, United States.
David C BellCenter for Nanoscale Systems, Harvard University, Cambridge, United States.
Gabriel BirraneDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States.ORCID 0000-0002-1759-5499
Maofu LiaoWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, United States.
Pamela A SilverDepartment of Systems Biology, Harvard Medical School, Boston, United States.
Boston University · USHarvard University · USBeth Israel Deaconess Medical Center · US

Funding

Thermo Scientific Glacios cryo-TEMS10OD030292 · OD · VANDERBILT UNIVERSITY · PI NAKAGAWA, TERUNAGA · 2021 to 2021
$2.0M
TFS Talos-L120C, a 120kV transmission electron microscope for structural studiesS10OD036307 · OD · VANDERBILT UNIVERSITY · PI NAKAGAWA, TERUNAGA · 2024 to 2024
$656k
Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften LPDS 2014-05German National Academy of Sciences Leopoldina LPDS 2014-05Gordon and Betty Moore Foundation 5506NIH HHS S10 OD030292NIH HHS S10 OD036307
6 · The paper itself

Abstract

Iron storage proteins are essential for cellular iron homeostasis and redox balance. Ferritin proteins are the major storage units for bioavailable forms of iron. Some organisms lack ferritins, and it is not known how they store iron. Encapsulins, a class of protein-based organelles, have recently been implicated in microbial iron and redox metabolism. Here, we report the structural and mechanistic characterization of a 42 nm two-component encapsulin-based iron storage compartment from

Indexed as

BacillaceaeBacterial ProteinsCeruloplasminCryoelectron MicroscopyCrystallography, X-RayFerritinsHomeostasisIronModels, MolecularOrganellesProtein ConformationBacterial ProteinsCeruloplasminFerritinsIronbiochemistrychemical biologyE. coliencapsulinsiron storagemolecular biophysicsprotein organellesquasibacillus thermotoleransstructural biology

Identifiers

PMID31282860
PMCPMC6668986
OpenAlexW2962608495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.