Evidence map›Paper›PMID 31282680›Full record

ArticleJournal of medicinal chemistry2019

Development of Inhibitors against

Andrew J Whitehouse, Sherine E Thomas, Karen P Brown, Alexander Fanourakis, Daniel S-H Chan, M Daben J Libardo, Vitor Mendes, Helena I M Boshoff, R Andres Floto, Chris Abell and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 45 citations in OpenAlex.

  1. Nicotinamide-Based Covalent Inhibitors of tRNA (mACS medicinal chemistry letters · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Ethyl Acetate Fraction ofAntibiotics (Basel, Switzerland) · 2022
    Article
  12. Article
  13. Article
  14. Potential therapeutic targets fromRSC medicinal chemistry · 2022
    Review
  15. Management ofEuropean respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Andrew J WhitehouseDepartment of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , U.K.
Sherine E ThomasDepartment of Biochemistry , University of Cambridge , Tennis Court Road , Cambridge CB2 1GA , U.K.
Karen P BrownMolecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular Biology , University of Cambridge , Francis Crick Avenue, Cambridge Biomedical Campus , Cambridge CB2 0QH , U.K.
Alexander FanourakisDepartment of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , U.K.
Daniel S-H ChanDepartment of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , U.K.
M Daben J LibardoTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease , National Institutes of Health , 9000 Rockville Pike , Bethesda, Maryland 20892 , United States.ORCID 0000-0003-0037-7812
Vitor MendesDepartment of Biochemistry , University of Cambridge , Tennis Court Road , Cambridge CB2 1GA , U.K.ORCID 0000-0002-2734-2444
Helena I M BoshoffTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease , National Institutes of Health , 9000 Rockville Pike , Bethesda, Maryland 20892 , United States.ORCID 0000-0002-4333-206X
R Andres FlotoMolecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular Biology , University of Cambridge , Francis Crick Avenue, Cambridge Biomedical Campus , Cambridge CB2 0QH , U.K.
Chris AbellDepartment of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , U.K.ORCID 0000-0001-9174-1987
Tom L BlundellDepartment of Biochemistry , University of Cambridge , Tennis Court Road , Cambridge CB2 1GA , U.K.
Anthony G CoyneDepartment of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , U.K.ORCID 0000-0003-0205-5630
University of Cambridge · GBMRC Laboratory of Molecular Biology · GBNational Institutes of Health · US

Funding

Development Of New Chemotherapeutics For TuberculosisZIAAI000693 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BARRY, CLIFTON · 2009 to 2025
$20.1M
Wellcome Trust 107032AIAWellcome Trust 200814/Z/16/ZWellcome Trust 200814_Z_16_Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Bacterial AgentsCrystallography, X-RayDrug DevelopmentEscherichia coli ProteinsHumansMycobacterium abscessusProtein Structure, SecondarytRNA MethyltransferasesAnti-Bacterial AgentsEscherichia coli ProteinsTrmD protein, E colitRNA Methyltransferases

Identifiers

PMID31282680
PMCPMC6691401
OpenAlexW3004647566

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.