Evidence map›Paper›PMID 31282290›Full record

ArticleEpigenetics

Epigenome-wide association study of DNA methylation and microRNA expression highlights novel pathways for human complex traits.

Tianxiao Huan, Michael Mendelson, Roby Joehanes, Chen Yao, Chunyu Liu, Ci Song, Anindya Bhattacharya, Jian Rong, Kahraman Tanriverdi, Joshua Keefe and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Epigenetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Tianxiao HuanThe National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.ORCID 0000-0001-5840-9413
Michael MendelsonThe National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.ORCID 0000-0001-7590-3958
Roby JoehanesThe National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.ORCID 0000-0001-5549-9054
Chen YaoThe National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.ORCID 0000-0002-3944-7788
Chunyu LiuThe National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.
Ci SongThe National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.
Anindya BhattacharyaDepartment of Computer Science and Engineering, University of California, San Diego, CA, USA.
Jian RongDepartment of Mathematics and Statistics, Boston University, Boston, MA, USA.
Kahraman TanriverdiDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Joshua KeefeThe National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.
Joanne M MurabitoThe National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.
Paul CourchesneThe National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.ORCID 0000-0001-5691-6913
Martin G LarsonThe National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.
Jane E FreedmanDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Daniel LevyThe National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.
National Heart Lung and Blood Institute · USBoston University · USUniversity of Massachusetts Chan Medical School · USUniversity of California San Diego · US

Funding

Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
Novel multi-omics approach to the biology of healthy aging: Framingham StudyR56AG029451 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LUNETTA, KATHRYN L, MURABITO, JOANNE M · 2015 to 2015
$474k
Circulating Epigenetic Biomarkers for Personalized Cardiovascular Disease PreventionK99HL136875 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI MENDELSON, MICHAEL MAXWELL · 2017 to 2018
$330k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K99 HL136875NHLBI NIH HHS N01 HC025195NIA NIH HHS R56 AG029451
6 · The paper itself

Abstract

DNA methylation (DNAm) and microRNAs (miRNAs) have been implicated in a wide-range of human diseases. While often studied in isolation, DNAm and miRNAs are not independent. We analyzed associations of expression of 283 miRNAs with DNAm at >400K CpG sites in whole blood obtained from 3565 individuals and identified 227 CpGs at which differential methylation was associated with the expression of 40 nearby miRNAs (

Indexed as

DNA MethylationEpigenomeMultifactorial InheritanceChromosomes, Human, Pair 14CpG IslandsEpigenomicsGenome-Wide Association StudyGenomic ImprintingHumansMenarcheMendelian Randomization AnalysisMicroRNAsQuantitative Trait LociTranscriptomeMicroRNAsage at menarchecomplex traitsDNA methylationeQTMmicroRNAmiR-eQTM

Identifiers

PMID31282290
PMCPMC6961684
OpenAlexW2955566655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.