ArticleJournal of clinical hypertension (Greenwich, Conn.)2019
METS-IR, a novel simple insulin resistance indexes, is associated with hypertension in normal-weight Chinese adults.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 3 of them syntheses that pooled it.
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Who cites it
93 citing papers in PubMed, 3 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- The triglyceride-glucose index is associated with a higher risk of hypertension: evidence from a cross-sectional study of Chinese adults and meta-analysis of epidemiology studies.Frontiers in endocrinology · 2025Pooled it
- Triglyceride-glucose index and obstructive sleep apnea: a systematic review and meta-analysis.Lipids in health and disease · 2024Pooled it
- Association Between Triglyceride-Glucose Index and Hypertension: A Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Insulin Resistance and Blood Pressure Control on Cognitive Outcomes.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- Stage-specific utility of obesity indices across the chronic kidney disease continuum.Renal failure · 2026Article
- Threshold effect of the METS-VF index on hyperuricemia in adults with hypertension: a cross-sectional study.BMC endocrine disorders · 2026Article
- Nonlinear association between metabolic score for insulin resistance (METS-IR) and prevalent hypertension: a cross-sectional study.BMC cardiovascular disorders · 2026Article
- Head-to-head comparison of fasting-insulin-based versus non-insulin-based insulin resistance surrogates for predicting all-cause and cardiovascular mortality in hypertensive adults across the glycemic continuum: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Age-related changes in METS-IR and HOMA-IR in obese adults and their relationship with cardiometabolic comorbidities.Archives of endocrinology and metabolism · 2026Article
- Association of four insulin resistance surrogates with anemia among middle-aged and elderly individuals: a cross-sectional study from the China Health and Retirement Longitudinal Study.BMC public health · 2026Article
- The Relationship Between Dynamic Changes in the Insulin Resistance-Related Indices and Metabolic Syndrome in Middle-Aged and Elderly Population.International journal of endocrinology · 2026Article
- Assessing the role of the Triglyceride-glucose related indices in identifying metabolic syndrome risk across body mass index categories.Endocrine · 2025Article
- Metabolic score for visceral fat (METS-VF) is associated with arterial stiffness progression in Type 2 diabetes: a retrospective cohort study of China.BMC endocrine disorders · 2025Article
- Associations of insulin resistance surrogate with resistant hypertension and the severity of hypertension in the chronic kidney disease population.Journal of hypertension · 2025Article
- The correlation between different metabolic scores and the risk of cardiometabolic comorbidities in hypertensive patients.Scientific reports · 2025Article
- Association Between Insulin Resistance and Incomplete Endothelization of LAAC Devices in Patients with Atrial Fibrillation: A Retrospective Study.Cardiology and therapy · 2025Article
- Association between the metabolic score for insulin resistance trajectory and new-onset metabolic syndrome: a retrospective cohort study based on health check-up data in China.Lipids in health and disease · 2025Article
- The Predictive Value of Insulin Resistance Surrogates for Diabetic Kidney Disease in Type 2 Diabetes Mellitus.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- Derivatives of the triglyceride-glucose index and their association with incident hypertension in prehypertensive individuals: a 4-year cohort study augmented by mendelian randomization.Cardiovascular diabetology · 2025Article
- Association Analysis of Insulin Resistance Metabolic Score (METS-IR) and Gestational Diabetes Mellitus: Based on National Health and Nutrition Examination Survey Database From 2007 to 2018.Endocrinology, diabetes & metabolism · 2025Article
33 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance (IR) plays a crucial role in the development of hypertension, so early recognition of IR is of substantial clinical importance for the management of hypertension. But traditional IR indexes are invasive, complex, and impractical. We aimed to evaluate the associations between three simple IR indexes and hypertension in different body mass index (BMI) categories. A total of 142 005 adults who did not take antihypertensive medication were included in this analysis. The ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDLc), the product of fasting triglycerides and glucose (TyG), and metabolic score for IR (METS-IR) were calculated according to the corresponding formulas. The associations between them and hypertension were analyzed by logistic regression. Among the three indicators, only METS-IR had positive correlations with blood pressure levels (all P < 0.001). After full adjustment, METS-IR was significantly associated with hypertension in the normal BMI group but not in the elevated BMI group. The OR for hypertension in the normal BMI group in the highest quartile of METS-IR was 2.884 (95% CI: 2.468-3.369) in the total sample, 1.915 (95% CI: 1.614-2.271) in females and 2.083 (95% CI: 1.717-2.527) in males. Our findings indicate that METS-IR, a simple and cost-effective IR index, was strongly associated with hypertension in normal-weight Chinese subjects. It could help monitor and manage hypertension in normal-weight individuals.
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