Evidence map›Paper›PMID 31282004›Full record

ReviewScandinavian journal of immunology2019

Role of exosomes in tumour and transplant immune regulation.

Diego A Lema, William J Burlingham

Open access · bronzeAbstract readReview
In one paragraph

Review in Scandinavian journal of immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Vaccine Adjuvants and Delivery Systems: A Comprehensive Review.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Exosomes: a promising avenue for cancer diagnosis beyond treatment.Frontiers in cell and developmental biology · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. The immune landscape of esophageal cancer.Cancer communications (London, England) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Diego A LemaDivision of Transplantation, Department of Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.ORCID https://orcid.org/0000-0001-7910-1127
William J BurlinghamDivision of Transplantation, Department of Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.ORCID https://orcid.org/0000-0002-2653-6044
University of Wisconsin–Madison · US

Funding

Natural vs. Pathogenic Th17 responses to col Va1, Ka1tubulin and vimentinR01AI119140 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SULLIVAN, JEREMY A · 2016 to 2020
$1.9M
Exosome-mediated Tolerance in combined Kidney and Stem Cell TransplantationR21AI147157 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI FOLEY, DAVID PAUL · 2019 to 2020
$426k
Detection of IL35+ Exosomes as a Marker for Peripheral ToleranceR03AI146688 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI FOLEY, DAVID PAUL · 2020 to 2021
$155k
NIAID NIH HHS R01 AI119140NIAID NIH HHS R03 AI146688NIAID NIH HHS R21 AI147157
6 · The paper itself

Abstract

Exosomes are a potent means for intercellular communication. However, exosomes have received intensive research focus in immunobiology only relatively recently. Because they transport proteins, lipids and genetic material between cells, they are especially suited to amplify their parental cell's message and overcome the physical constraints of cell-to-cell contact, that is exosome release gives cells the ability to alter distant, non-contiguous cells. As progress is made in this field, it has become increasingly obvious that exosomes are involved in most biological processes. In the immune system, exosomes are fundamental tools used by every immune cell type to fulfil its function and promote inflammation or tolerance. In this review, we first summarize key aspects of immune cell-specific exosomes and their functions. Then, we describe how exosomes have been shown to be indispensable orchestrators of the immune response in two immunological scenarios, namely transplant rejection or tolerance, and tumour evasion or initiation of anti-tumour immune responses.

Indexed as

Biological TransportB-LymphocytesCell CommunicationDendritic CellsExosomesGraft RejectionHumansImmune ToleranceNeoplasmsSignal TransductionT-Lymphocytes, RegulatoryTumor EscapeanergyB cellscancercell surface moleculescostimulationdendritic cellsmajor histocompatibility complexsuppressionT cellstolerancetransplantationtumor immunity

Identifiers

PMID31282004
PMCPMC7050771
OpenAlexW2961228074

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.