Evidence map›Paper›PMID 31281889›Full record

ArticleScience advances2019

Bioresorbable optical sensor systems for monitoring of intracranial pressure and temperature.

Jiho Shin, Zhonghe Liu, Wubin Bai, Yonghao Liu, Ying Yan, Yeguang Xue, Irawati Kandela, Maryam Pezhouh, Matthew R MacEwan, Yonggang Huang and 3 more

Abstract read
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

  1. Article
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  9. Article
  10. Biomimetic fabricated tubular graftBioactive materials · 2025
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  11. Article
  12. Article
  13. CMOS-compatible reconstructive spectrometers with self-referencing integrated Fabry-Perot resonators.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Design and Development of Transient Sensing Devices for Healthcare Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiho ShinDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Zhonghe LiuDepartment of Electrical Engineering, University of Texas at Arlington, Arlington, TX 76019, USA.ORCID 0000-0002-9629-110X
Wubin BaiDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-2872-5559
Yonghao LiuDepartment of Electrical Engineering, University of Texas at Arlington, Arlington, TX 76019, USA.
Ying YanDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yeguang XueDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-1968-5092
Irawati KandelaDevelopmental Therapeutics Core, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-8646-9357
Maryam PezhouhNorthwestern Medicine, Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA.
Matthew R MacEwanDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yonggang HuangDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-0483-8359
Wilson Z RayDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Weidong ZhouDepartment of Electrical Engineering, University of Texas at Arlington, Arlington, TX 76019, USA.ORCID 0000-0002-8620-4957
John A RogersDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-3830-5980

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
NCI NIH HHS P30 CA060553
6 · The paper itself

Abstract

Continuous measurements of pressure and temperature within the intracranial, intraocular, and intravascular spaces provide essential diagnostic information for the treatment of traumatic brain injury, glaucoma, and cardiovascular diseases, respectively. Optical sensors are attractive because of their inherent compatibility with magnetic resonance imaging (MRI). Existing implantable optical components use permanent, nonresorbable materials that must be surgically extracted after use. Bioresorbable alternatives, introduced here, bypass this requirement, thereby eliminating the costs and risks of surgeries. Here, millimeter-scale bioresorbable Fabry-Perot interferometers and two dimensional photonic crystal structures enable precise, continuous measurements of pressure and temperature. Combined mechanical and optical simulations reveal the fundamental sensing mechanisms. In vitro studies and histopathological evaluations quantify the measurement accuracies, operational lifetimes, and biocompatibility of these systems. In vivo demonstrations establish clinically relevant performance attributes. The materials, device designs, and fabrication approaches outlined here establish broad foundational capabilities for diverse classes of bioresorbable optical sensors.

Indexed as

Absorbable ImplantsBiosensing TechniquesMonitoring, PhysiologicHumansInterferometryIntracranial PressureMagnetic Resonance ImagingOptical DevicesPhotonsSiliconTemperatureSilicon

Identifiers

PMID31281889
PMCPMC6611687

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.