ArticleApplied materials today2019
The Design and
Article in Applied materials today, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 121 citations in OpenAlex.
- Biochemical and Physicomechanical Cues of Biomaterials Guide Osteogenic Differentiation of Mesenchymal Stem Cells.International journal of molecular sciences · 2026Review
- AI-Assisted Design and Evaluation of SLM-Ti64 Implants for Enhanced Bone Regeneration.Advanced healthcare materials · 2025Article
- Biomechanical implications of femoral neck system removal following femoral neck fracture treatment in low bone mineral density conditions.Scientific reports · 2025Article
- Surgical factors that contribute to tibial periprosthetic fracture after cementless Oxford Unicompartmental Knee Replacement: a finite element analysis.Frontiers in bioengineering and biotechnology · 2025Article
- Design of internal fixation implants for fracture: A review.Journal of orthopaedic translation · 2025Review
- Selective laser melting fabrication of functionally graded macro-porous Ti-6Al-4V scaffold for cavity bone defect reconstruction.Frontiers in bioengineering and biotechnology · 2025Article
- Implant Strength Contributes to the Osseointegration Strength of Porous Metallic Materials.Journal of biomechanical engineering · 2024Article
- The role of collagen and crystallinity in the physicochemical properties of naturally derived bone grafts.Regenerative biomaterials · 2024Article
- Flexible multifunctional titania nanotube array platform for biological interfacing.MRS bulletin · 2024Article
- Bio-functional hydroxyapatite-coated 3D porous polyetherketoneketone scaffold for enhanced osteogenesis and osteointegration in orthopedic applications.Regenerative biomaterials · 2024Article
- Integrating Melt Electrowriting and Fused Deposition Modeling to Fabricate Hybrid Scaffolds Supportive of Accelerated Bone Regeneration.Advanced healthcare materials · 2024Article
- Titanium Alloy Implants with Lattice Structures for Mandibular Reconstruction.Materials (Basel, Switzerland) · 2023Review
- Geometric Mismatch Promotes Anatomic Repair in Periorbital Bony Defects in Skeletally Mature Yucatan Minipigs.Advanced healthcare materials · 2023Article
- [Three-dimensional-printed hemi-pelvic prosthesis for revision of aseptic loosening or screw fracture of modular hemi-pelvic prosthesis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023Article
- Titanium Lattice Structures Produced via Additive Manufacturing for a Bone Scaffold: A Review.Journal of functional biomaterials · 2023Review
- Bioreactor analyses of tissue ingrowth, ongrowth and remodelling around implants: An alternative to live animal testing.Frontiers in bioengineering and biotechnology · 2023Article
- The effect of nodal connectivity and strut density within stochastic titanium scaffolds on osteogenesis.Frontiers in bioengineering and biotechnology · 2023Article
- Additively manufactured metallic biomaterials.Bioactive materials · 2022Review
- Approach to the Fatigue and Cellular Behavior of Superficially Modified Porous Titanium Dental Implants.Materials (Basel, Switzerland) · 2022Article
- Total and partial knee arthroplasty implants that maintain native load transfer in the tibia.Bone & joint research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
An increasing volume of work supports utilising the mechanobiology of bone for bone ingrowth into a porous scaffold. However, typically during in vivo testing of implants, the mechanical properties of the bone being replaced are not quantified. Consequently there remains inconsistencies in the literature regarding 'optimum' pore size and porosity for bone ingrowth. It is also difficult to compare ingrowth results between studies and to translate in vivo animal testing to human subjects without understanding the mechanical environment. This study presents a clinically applicable approach to determining local bone mechanical properties and design of a scaffold with similar properties. The performance of the scaffold was investigated in vivo in an ovine model. The density, modulus and strength of trabecular bone from the medial femoral condyle from ovine bones was characterised and power-law relationships were established. A porous titanium scaffold, intended to maintain bone mechanical homeostasis, was additively manufactured and implanted into the medial femoral condyle of 6 ewes. The stiffness of the scaffold varied throughout the heterogeneous structure and matched the stiffness variation of bone at the surgical site. Bone ingrowth into the scaffold was 10.73±2.97% after 6 weeks. Fine woven bone, in the interior of the scaffold, and intense formations of more developed woven bone overlaid with lamellar bone at the implant periphery were observed. The workflow presented will allow future in vivo testing to test specific bone strains on bone ingrowth in response to a scaffold and allow for better translation from in vivo testing to commercial implants.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.