Evidence map›Paper›PMID 31281867›Full record

ArticleOpen forum infectious diseases2019

Extensively Drug-Resistant

Ayesha Khan, Truc T Tran, Rafael Rios, Blake Hanson, William C Shropshire, Zhizeng Sun, Lorena Diaz, An Q Dinh, Audrey Wanger, Luis Ostrosky-Zeichner and 3 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 51 citations in OpenAlex.

  1. Antimicrobial agents and chemotherapy · 2026
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  3. Sphingosine synergizes with polymyxin antibiotics againstMicrobiology (Reading, England) · 2026
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  4. Article
  5. Article
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  7. Article
  8. Molecular Epidemiology of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026
    Article
  9. Article
  10. First nationwide survey onAntimicrobial agents and chemotherapy · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Outbreak ofAntibiotics (Basel, Switzerland) · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Ayesha KhanCenter for Antimicrobial Resistance and Microbial Genomics, McGovern School of Medicine, Houston.
Truc T TranCenter for Antimicrobial Resistance and Microbial Genomics, McGovern School of Medicine, Houston.
Rafael RiosMolecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogotá, Colombia.
Blake HansonCenter for Antimicrobial Resistance and Microbial Genomics, McGovern School of Medicine, Houston.
William C ShropshireCenter for Antimicrobial Resistance and Microbial Genomics, McGovern School of Medicine, Houston.
Zhizeng SunPharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas.
Lorena DiazCenter for Antimicrobial Resistance and Microbial Genomics, McGovern School of Medicine, Houston.
An Q DinhCenter for Antimicrobial Resistance and Microbial Genomics, McGovern School of Medicine, Houston.
Audrey WangerCenter for Antimicrobial Resistance and Microbial Genomics, McGovern School of Medicine, Houston.
Luis Ostrosky-ZeichnerCenter for Antimicrobial Resistance and Microbial Genomics, McGovern School of Medicine, Houston.
Timothy PalzkillPharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas.
Cesar A AriasCenter for Antimicrobial Resistance and Microbial Genomics, McGovern School of Medicine, Houston.
William R MillerCenter for Antimicrobial Resistance and Microbial Genomics, McGovern School of Medicine, Houston.ORCID 0000-0002-1518-2973
CNR de la Résistance aux Antibiotiques · FRUniversidad El Bosque · COBaylor College of Medicine · US

Funding

BETA-LACTAMASE MUTATIONS IN ANTIBIOTIC RESISTANCER01AI032956 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI Timothy Palzkill · 1992 to 2026
$6.5M
The LiaFSR system and antimicrobial peptide resistance in enterococciR01AI134637 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Cesar Augusto Arias · 2018 to 2026
$3.7M
POR Program on Genomic Prediction of Antimicrobial Resistance in VREK24AI121296 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2016 to 2025
$1.5M
Role of YxdJK and DAK in the Enterococcal Envelope Stress ResponseK08AI135093 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILLER, WILLIAM R · 2018 to 2022
$929k
Daptomycin Resistance in Enterococcus faeciumK08AI113317 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TRAN, TRUC THANH · 2014 to 2018
$792k
Molecular basis of the cefazolin inoculum effectR21AI143229 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2019 to 2020
$442k
NIAID NIH HHS K08 AI113317NIAID NIH HHS K08 AI135093NIAID NIH HHS K24 AI121296NIAID NIH HHS R01 AI032956NIAID NIH HHS R01 AI134637NIAID NIH HHS R21 AI143229
6 · The paper itself

Abstract

backgroundTreatment of serious infections due to multidrug-resistant (MDR)

methodsIsolates were sequenced using both short-read (Illumina) and long-read technology to identify resistance determinants, polymorphisms (compared with

resultsTwo ST309

conclusionsThe presence of tandem GES-19 and GES-26 is associated with resistance to all β-lactams, including ceftolozane/tazobactam. Phylogenetic analysis suggests that ST309

Indexed as

carbapenem-resistant Pseudomonas aeruginosaceftolozane/tazobactamcombination therapyGES beta-lactamase

Identifiers

PMID31281867
PMCPMC6602888
OpenAlexW2955613392

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.