Evidence map›Paper›PMID 31281804›Full record

ArticleCanadian journal of gastroenterology & hepatology2019

Ischemic Postconditioning (IPostC) Protects Fibrotic and Cirrhotic Rat Livers after Warm Ischemia.

Julia Schewe, Marie-Christine Makeschin, Ingrid Liss, Doris Mayr, Jiang Zhang, Andrej Khandoga, Simon Rothenfußer, Max Schnurr, Alexander L Gerbes, Christian J Steib

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of gastroenterology & hepatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. [D-AlaFrontiers in surgery · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Julia ScheweBerlin Institute of Health Charité - Universitätsmedizin Berlin, Germany.
Marie-Christine MakeschinDepartment of Pathology, University of Munich, Campus Grosshadern, Munich, Germany.
Ingrid LissDepartment of Medicine II, University Hospital, Liver Centre Munich, LMU Munich, Germany.
Doris MayrDepartment of Pathology, University of Munich, Campus Grosshadern, Munich, Germany.
Jiang ZhangDepartment of Medicine II, University Hospital, Liver Centre Munich, LMU Munich, Germany.
Andrej KhandogaDepartment of Surgery, University of Munich, Campus Grosshadern, Munich, Germany.
Simon RothenfußerDivision of Clinical Pharmacology, University of Munich, Campus Innenstadt, Munich, Germany.
Max SchnurrDivision of Clinical Pharmacology, University of Munich, Campus Innenstadt, Munich, Germany.
Alexander L GerbesDepartment of Medicine II, University Hospital, Liver Centre Munich, LMU Munich, Germany.
Christian J SteibDepartment of Medicine II, University Hospital, Liver Centre Munich, LMU Munich, Germany.ORCID 0000-0002-4748-8248
Ludwig-Maximilians-Universität München · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Decreased organ function following liver resection is a major clinical issue. The practical method of ischemic postconditioning (IPostC) has been studied in heart diseases, but no data exist regarding fibrotic livers. Aims: We aimed to determine whether IPostC could protect healthy, fibrotic, and cirrhotic livers from ischemia reperfusion injury (IRI). Methods: Fibrosis was induced in male SD rats using bile duct ligation (BDL, 4 weeks), and cirrhosis was induced using thioacetamide (TAA, 18 weeks). Fibrosis and cirrhosis were histologically confirmed using HE and EvG staining. For healthy, fibrotic, and cirrhotic livers, isolated liver perfusion with 90 min of warm ischemia was performed in three groups (each with n=8): control, IPostC 8x20 sec, and IPostC 4x60 sec. additionally, healthy livers were investigated during a follow-up study. Lactate dehydrogenase (LDH) and thromboxane B Results: LDH and TXB Conclusion: IPostC following warm ischemia protects healthy, fibrotic, and cirrhotic livers against IRI. Reduced efflux of TXB

Indexed as

Ischemic PostconditioningAnimalsDisease Models, AnimalLiverLiver CirrhosisMaleRatsRats, Sprague-DawleyReperfusion InjuryWarm Ischemia

Identifiers

PMID31281804
PMCPMC6590494
OpenAlexW2948301408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.