ArticleQuantitative imaging in medicine and surgery2019
A portable three-dimensional photoacoustic tomography system for imaging of chronic foot ulcers.
Article in Quantitative imaging in medicine and surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.Journal of biomedical optics · 2022Pooled it
- Radiomics-driven perfusion prediction in clinical photoacoustic foot imaging.Photoacoustics · 2025Article
- High-resolution three-dimensional quantitative photoacoustic and ultrasound imaging of subcutaneous microvasculature in extremities.Biomedical optics express · 2025Article
- Recent advancements in molecular photoacoustic tomography.JPhys photonics · 2025Review
- Enhanced clinical photoacoustic vascular imaging through a skin localization network and adaptive weighting.Photoacoustics · 2025Article
- Article
- Emerging Photoacoustic Imaging Techniques for Peripheral Arterial Disease.Current treatment options in cardiovascular medicine · 2025Review
- Article
- Unsupervised denoising of photoacoustic images based on the Noise2Noise network.Biomedical optics express · 2024Article
- Photoacoustic imaging of peripheral vessels in extremities by large-scale synthetic matrix array.Journal of biomedical optics · 2024Article
- Dual-Scan Photoacoustic Tomography for the Imaging of Vascular Structure on Foot.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Heavy water coupling gel for short-wave infrared photoacoustic imaging.Journal of biomedical optics · 2023Article
- Panoramic volumetric clinical handheld photoacoustic and ultrasound imaging.Photoacoustics · 2023Article
- Viewing life without labels under optical microscopes.Communications biology · 2023Review
- Automatic force-controlled 3D photoacoustic system for human peripheral vascular imaging.Biomedical optics express · 2023Article
- Photoacoustic imaging to monitor outcomes during hyperbaric oxygen therapy: validation in a small cohort and case study in a bilateral chronic ischemic wound.Biomedical optics express · 2022Article
- Monitoring peripheral hemodynamic response to changes in blood pressure via photoacoustic imaging.Photoacoustics · 2022Article
- Photoacoustic Enhancement of Ferricyanide-Treated Silver Chalcogenide-Coated Gold Nanorods.The journal of physical chemistry. C, Nanomaterials and interfaces · 2022Article
- Photoacoustic monitoring of angiogenesis predicts response to therapy in healing wounds.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Article
- Photoacoustic imaging as a highly efficient and precise imaging strategy for the evaluation of brain diseases.Quantitative imaging in medicine and surgery · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChronic leg ulcers affect approximately 6.5 million Americans and the disorder is associated with a range of serious complications. Since many chronic ulcers have underlying vascular insufficiency, accurate assessment of tissue perfusion is critical to treatment planning and post-surgical monitoring. However, existing clinical tests fail to meet this need in practice due to their low sensitivity or accuracy.
methodsIn this paper, we introduce a portable photoacoustic tomography (PAT) system for wound assessment. Since hemoglobin serves as the major endogenous contrast at near-infrared wavelengths, PAT provides label-free, three-dimensional (3D) imaging of hemoglobin distribution, which is closely related to blood perfusion. The proposed system consists of a 128-element linear transducer array, a data acquisition (DAQ) system, and a pulsed Nd:YAG laser source, all mounted on a portable cart for easy clinical testing.
resultsWe validated our system through both phantom and human imaging studies. The phantom imaging results indicate that the system's spatial resolution ranges from 0.5 mm along the axial direction to 1.3 mm along the elevational direction. The healthy volunteer result shows clear foot vasculature, indicating good perfusion. The preliminary patient imaging results agree very well with the clinical test, demonstrating that PAT has a high potential for assessing the circulation around the wound.
conclusionsWe believe that our technique will be a valuable tool for assessing tissue perfusion and guiding wound treatment in vascular clinics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.