Evidence map›Paper›PMID 31281773›Full record

ArticleQuantitative imaging in medicine and surgery2019

Designing visible-light optical coherence tomography towards clinics.

Xiao Shu, Lisa Beckmann, Yuanbo Wang, Ian Rubinoff, Katie Lucy, Hiroshi Ishikawa, Gadi Wollstein, Amani A Fawzi, Joel S Schuman, Roman V Kuranov and 1 more

Abstract read
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Advances in Wearable Bioimaging.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  2. Development of an optically emulated computed tomography scanner for college education.Visual computing for industry, biomedicine, and art · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Frontiers in ophthalmology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Optical Coherence Tomography and Glaucoma.Annual review of vision science · 2021
    Review
  18. Advances in Retinal Oximetry.Translational vision science & technology · 2021
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiao ShuDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Lisa BeckmannDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Yuanbo WangOpticent Health, Evanston, IL, USA.
Ian RubinoffDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Katie LucyNYU Langone Eye Center, NYU School of Medicine, New York, NY, USA.
Hiroshi IshikawaNYU Langone Eye Center, NYU School of Medicine, New York, NY, USA.
Gadi WollsteinNYU Langone Eye Center, NYU School of Medicine, New York, NY, USA.
Amani A FawziDepartment of Ophthalmology, Northwestern University, Chicago, IL, USA.
Joel S SchumanNYU Langone Eye Center, NYU School of Medicine, New York, NY, USA.
Roman V KuranovDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Hao F ZhangDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.

Funding

Visible-light optical coherence tomography for clinical glaucoma managementR44EY026466 · NEI · OPTICENT, INC. · PI KURANOV, ROMAN · 2018 to 2023
$2.7M
Investigating oxygen metabolism in diabetic retinopathyR01EY026078 · NEI · NORTHWESTERN UNIVERSITY · PI SHEIBANI, NADER, ZHANG, HAO F · 2016 to 2020
$2.3M
Investigating nanoscale neuronal damages in early glaucoma towards clinical optical detectionR01EY029121 · NEI · NORTHWESTERN UNIVERSITY · PI LIU, XIAORONG, ZHANG, HAO F · 2018 to 2021
$2.0M
Functional Retinal Imaging to Monitor Pharmaco-Therapies in Diabetic RetinopathyDP3DK108248 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FAWZI, AMANI A, ZHANG, HAO F · 2015 to 2015
$1.9M
Mechanisms underlying the formation of the cornea and ocular surface epitheliumR01EY028304 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KUME, TSUTOMU · 2018 to 2021
$1.6M
Visual Sciences T32T32EY025202 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Gregory William Schwartz · 2015 to 2026
$1.4M
Method for accurate retinal oxygen metabolic rate extractionR43EY028475 · NEI · OPTICENT, INC. · PI WANG, YUANBO · 2017 to 2017
$225k
NEI NIH HHS R01 EY026078NEI NIH HHS R01 EY028304NEI NIH HHS R01 EY029121NEI NIH HHS R43 EY028475NEI NIH HHS R44 EY026466NEI NIH HHS T32 EY025202NIDDK NIH HHS DP3 DK108248
6 · The paper itself

Abstract

backgroundThe capabilities of visible-light optical coherence tomography (vis-OCT) in noninvasive anatomical and functional retinal imaging have been demonstrated by multiple groups in both rodents and healthy human subjects. Translating laboratory prototypes to an integrated clinical-environment-friendly system is required to explore the full potential of vis-OCT in disease management.

methodsWe developed and optimized a portable vis-OCT system for human retinal imaging in clinical settings. We acquired raster- and circular-scan images from both healthy and diseased human eyes.

resultsThe new vis-OCT provided high-quality retinal images of both subjects without any known eye diseases and patients with various retinal diseases, including retinal occlusive disease and diabetic retinopathy (DR) over a broad range of ages.

conclusionsA newly designed vis-OCT system is sufficiently optimized to be suited for routine patients' examinations in clinics. Vis-OCT has the potential to add new anatomical and functional imaging capabilities to ophthalmic clinical care.

Indexed as

high resolution imagingophthalmologyOptical coherence tomography (OCT)

Identifiers

PMID31281773
PMCPMC6571199

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.