Evidence map›Paper›PMID 31281685›Full record

ArticleCase reports in hematology2019

Biological versus Clinical Risk Factors in Acute Myeloid Leukemia: Is There a Winner?

M Malagola, N Polverelli, V Cancelli, E Morello, A Turra, E Borlenghi, F Cattina, B Rambaldi, S Bernardi, C Zanaglio and 4 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

M MalagolaChair of Hematology, Department of Clinical and Surgical Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST-Spedali Civili, Brescia, Italy.ORCID 0000-0003-0907-130X
N PolverelliChair of Hematology, Department of Clinical and Surgical Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST-Spedali Civili, Brescia, Italy.ORCID 0000-0001-6297-9697
V CancelliChair of Hematology, Department of Clinical and Surgical Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST-Spedali Civili, Brescia, Italy.ORCID 0000-0002-0063-9002
E MorelloChair of Hematology, Department of Clinical and Surgical Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST-Spedali Civili, Brescia, Italy.
A TurraChair of Hematology, Department of Clinical and Surgical Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST-Spedali Civili, Brescia, Italy.ORCID 0000-0003-4257-3862
E BorlenghiUnit of Hematology, ASST-Spedali Civili, Brescia, Italy.
F CattinaChair of Hematology, Department of Clinical and Surgical Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST-Spedali Civili, Brescia, Italy.ORCID 0000-0002-9988-2634
B RambaldiChair of Hematology, Department of Clinical and Surgical Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST-Spedali Civili, Brescia, Italy.
S BernardiChair of Hematology, Department of Clinical and Surgical Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST-Spedali Civili, Brescia, Italy.ORCID 0000-0002-3494-2624
C ZanaglioChair of Hematology, Department of Clinical and Surgical Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST-Spedali Civili, Brescia, Italy.
Elif Dereli EkeChair of Hematology, Department of Clinical and Surgical Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST-Spedali Civili, Brescia, Italy.
L GandolfiChair of Hematology, Department of Clinical and Surgical Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST-Spedali Civili, Brescia, Italy.
M FarinaChair of Hematology, Department of Clinical and Surgical Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST-Spedali Civili, Brescia, Italy.
D RussoChair of Hematology, Department of Clinical and Surgical Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST-Spedali Civili, Brescia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of a patient with a three-month history of peripheral blood cytopenia without a confirmed diagnosis of myelodysplastic syndrome, who developed a favourable-risk acute myeloid leukemia (AML), according to the European Leukemia Net (ELN) criteria. The patient achieved a complete remission with incomplete platelet recovery (CRi) after induction. The patient achieved the morphological CR after the first consolidation and completed the first-line treatment with a syngeneic stem cell transplantation (SCT). A disease relapse occurred after one year of CR (blast cell count in the bone marrow 15%), and the patient was offered a haplo-SCT, which he refused due to personal reasons. In this paper, we discuss the interplay between clinical and biological risk factors in non-high-risk AML patients and speculate that some old clinical risk factors (e.g., age of the patient, achievement of CR after induction, and previous history of myelodysplastic syndrome) may still impact on the treatment decision algorithm of some of these patients.

Identifiers

PMID31281685
PMCPMC6594262

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.