Evidence map›Paper›PMID 31281596›Full record

ArticleOxidative medicine and cellular longevity2019

Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr

Layla Aparecida Chisté, Beatriz Peters Pereira, Marcella Leite Porto, Jairo Pinto de Oliveira, Arícia Leone Evangelista Monteiro de Assis, Breno Valentim Nogueira, Silvana Santos Meyrelles, Tadeu Uggere de Andrade, Manuel Campos-Toimil, Elisardo Corral Vasquez and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Layla Aparecida ChistéPharmaceutical Sciences Graduate Program, Vila Velha University (UVV), Vila Velha, ES, Brazil.
Beatriz Peters PereiraPharmaceutical Sciences Graduate Program, Vila Velha University (UVV), Vila Velha, ES, Brazil.
Marcella Leite PortoFederal Institute of Education, Science, and Technology (IFES), Vila Velha, ES, Brazil.
Jairo Pinto de OliveiraLaboratory of Cellular Ultrastructure Carlos Alberto Redins (LUCCAR), Department of Morphology, Health Sciences Center, Federal University of Espirito Santo (UFES), Vitoria, ES, Brazil.
Arícia Leone Evangelista Monteiro de AssisLaboratory of Cellular Ultrastructure Carlos Alberto Redins (LUCCAR), Department of Morphology, Health Sciences Center, Federal University of Espirito Santo (UFES), Vitoria, ES, Brazil.
Breno Valentim NogueiraLaboratory of Cellular Ultrastructure Carlos Alberto Redins (LUCCAR), Department of Morphology, Health Sciences Center, Federal University of Espirito Santo (UFES), Vitoria, ES, Brazil.
Silvana Santos MeyrellesLaboratory of Translational Physiology, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES, Brazil.ORCID 0000-0003-0167-4093
Tadeu Uggere de AndradePharmaceutical Sciences Graduate Program, Vila Velha University (UVV), Vila Velha, ES, Brazil.
Manuel Campos-ToimilPharmacology of Chronic Diseases (CDPHARMA), Molecular Medicine and Chronic Diseases Research Center (CIMUS), University of Santiago de Compostela, Santiago de Compostela, Spain.ORCID 0000-0003-3674-3749
Elisardo Corral VasquezPharmaceutical Sciences Graduate Program, Vila Velha University (UVV), Vila Velha, ES, Brazil.
Bianca Prandi CampagnaroPharmaceutical Sciences Graduate Program, Vila Velha University (UVV), Vila Velha, ES, Brazil.ORCID 0000-0002-9023-4892
Thiago Melo Costa PereiraPharmaceutical Sciences Graduate Program, Vila Velha University (UVV), Vila Velha, ES, Brazil.ORCID 0000-0003-4053-5061
Universidade Vila Velha · BRUniversidade Federal do Espírito Santo · BRUniversidade de Santiago de Compostela · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExcessive consumption of soft drinks (SD) has become a health problem worldwide due to its association with related cardiovascular diseases. We investigated the possible impacts associated with the consumption of Brazilian guarana (normal and zero) SD in dyslipidemic mice, thus mitigating potential clinical confounders such as poor-quality diet, lifestyle, body composition, and/or comorbidities.

methodsSixteen-month-old LDLr

resultsGuarana soft drinks increased atherosclerosis (~60%) and were associated with hypercholesterolemia, hypertension, oxidative stress, DNA fragmentation, and apoptosis (~2-fold) of blood cells, besides presenting an increase in liver and gastric damage even in normoglycemia. Interestingly, Z-GSD did not cause the aforementioned changes, except in hemodynamic and renal parameters.

conclusionsChronic administration of GSD is prooxidative, compromising the cardiovascular, gastric, and hepatic systems; the effects are due at least in part to free sugar consumption but not to guarana extract per se.

Indexed as

AnimalsAtherosclerosisCarbonated BeveragesDNA DamageMiceOxidative StressPaullinia

Identifiers

PMID31281596
PMCPMC6590538
OpenAlexW2950735084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.