ArticleOxidative medicine and cellular longevity2019
Function, Oxidative, and Inflammatory Stress Parameters in Immune Cells as Predictive Markers of Lifespan throughout Aging.
Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Markers of the ageing macrophage: a systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- Trial
- The use of a bed with an insulating system of electromagnetic fields improves immune function, redox and inflammatory states, and decrease the rate of aging.Environmental health : a global access science source · 2020Trial
- Resilient Biophysical Phenotype of Memory CD4Immunology · 2026Article
- Interplay between Peripheral and Central Nervous System Myeloid Cells during Aging: Impact for Lade-Life Depression and Alzheimer's Disease.Neuroimmunomodulation · 2026Review
- iPSCs derived sEVs ameliorate NK cell senescence by targeting CISH-STAT3.Stem cell research & therapy · 2025Article
- Aging and immunity: the age-old tango.Genes & development · 2025Review
- Shortening of the telomere length during the transition period of dairy cows in relation to biological stress.Scientific reports · 2024Article
- Cannabidiol, a Strategy in Aging to Improve Redox State and Immunity in Male Rats.International journal of molecular sciences · 2024Article
- Intracellular cytokines in peritoneal leukocytes relate to lifespan in aging and long-lived female mice.Biogerontology · 2024Article
- Physical Activity and Oxidative Stress in Aging.Antioxidants (Basel, Switzerland) · 2024Review
- Predictive Models of Life Span in Old Female Mice Based on Immune, Redox, and Behavioral Parameters.International journal of molecular sciences · 2024Article
- The immunity and redox clocks in mice, markers of lifespan.Scientific reports · 2024Article
- The Nrf2-HO-1 system and inflammaging.Frontiers in immunology · 2024Review
- Components of the Glutathione Cycle as Markers of Biological Age: An Approach to Clinical Application in Aging.Antioxidants (Basel, Switzerland) · 2023Article
- Article
- Phototoxic or Photoprotective?-Advances and Limitations of Titanium (IV) Oxide in Dermal Formulations-A Review.International journal of molecular sciences · 2023Review
- Integrated multi-omics analysis of Alzheimer's disease shows molecular signatures associated with disease progression and potential therapeutic targets.Scientific reports · 2023Article
- Applying the AFRAID and FRIGHT Clocks to Novel Preclinical Mouse Models of Polypharmacy.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities.Cell & bioscience · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to the oxidative-inflammatory theory of aging, there is a link between the function, the oxidative-inflammatory stress state of immune cells, and longevity. However, it is unknown which immune cell parameters can predict lifespan and if there would be any changes in this prediction, depending on the age of the subject. Therefore, a longitudinal study in mice was performed analysing immune function (chemotaxis of macrophages and lymphocytes, phagocytosis of macrophages, natural killer (NK) activity, and lymphoproliferation capacity), antioxidant (catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities as well as reduced glutathione (GSH) concentrations), oxidant (oxidized glutathione (GSSG), superoxide anion, and malondialdehyde (MDA) concentrations), and inflammation-related markers (basal release of IL-1
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.