Evidence map›Paper›PMID 31281543›Full record

ArticleTheranostics2019

Impaired Regeneration Potential in Urinary Stem Cells Diagnosed from the Patients with Diabetic Nephropathy.

Geng Xiong, Weiqing Tang, Deying Zhang, David He, Guanghui Wei, Antony Atala, Xing-Jie Liang, Anthony J Bleyer, Michael E Bleyer, Jie Yu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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  14. miR-122-5p Regulates Renal Fibrosis In Vivo.International journal of molecular sciences · 2022
    Article
  15. Review
  16. Article
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  18. Article
  19. TUNEL Assay: A Powerful Tool for Kidney Injury Evaluation.International journal of molecular sciences · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Geng XiongDepartment of Pediatric Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Weiqing TangThe MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, China.
Deying ZhangWake Forest Institute for Regenerative Medicine, Winston-Salem, NC, USA.
David HeDepartment of Urology, Children Hospital of Chongqing Medical University, Chongqing, China.
Guanghui WeiDepartment of Urology, Children Hospital of Chongqing Medical University, Chongqing, China.
Antony AtalaWake Forest Institute for Regenerative Medicine, Winston-Salem, NC, USA.
Xing-Jie LiangChinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, China.
Anthony J BleyerSection on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Michael E BleyerSection on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jie YuDepartment of Obstetrics and Gynecology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Joseph A AloiDepartment of Endocrinology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jian-Xing MaDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Cristina M FurduiDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Yuanyuan ZhangWake Forest Institute for Regenerative Medicine, Winston-Salem, NC, USA.
Wake Forest University · USChildren's Hospital of Chongqing Medical University · CNBeijing Hospital · CNChinese Academy of Sciences · CNChongqing Medical University · CNUniversity of Oklahoma Health Sciences Center · US

Funding

Chronic Kidney Disease (CKD) Biomarkers Consortium Data Coordinating CenterU01DK103225 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI SCHRAUBEN, SARAH JEANNE · 2014 to 2020
$5.5M
NIDDK NIH HHS U01 DK103225
6 · The paper itself

Abstract

Stem cells present in urine possess regenerative capacity to repair kidney injury. However, the unique characteristics of urinary stem cells (USC) from patients with diabetic nephropathy (d-USC) are unknown. The goal of this study was to investigate stemness properties in cell phenotype and regenerative potential of d-USC, compared to USC from healthy individuals.

Indexed as

AgedApoptosisBlotting, WesternCell ProliferationCells, CulturedDiabetic NephropathiesFlow CytometryHumansKaryotypeKidney TubulesMicroscopy, Electron, TransmissionMiddle AgedOxidative StressStem CellsTelomeraseTOR Serine-Threonine KinasesMTOR protein, humanTelomeraseTOR Serine-Threonine Kinasesdiabetic nephropathyrenal insufficiencystem cellsurine

Identifiers

PMID31281543
PMCPMC6592174
OpenAlexW2950766369

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.