Evidence map›Paper›PMID 31281529›Full record

ReviewTheranostics2019

New insights into the pathogenesis and treatment of sarcopenia in chronic heart failure.

Jiayu Yin, Xiang Lu, Zhiyuan Qian, Weiting Xu, Xiang Zhou

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06298825 (Effect of Sarcopenia on Prognosis of Patients With Acute Decompensated Heart Failure), which is not on this map. Cited by 82 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 8 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06298825 unknown statusnot on this mapstarted 2024, after this paper: background citation

Effect of Sarcopenia on Prognosis of Patients With Acute Decompensated Heart Failure: a Prospective, Multi-center, Observational Cohort Study

TypeobservationalSponsorGuangdong Provincial People's HospitalRan2024 to 2026Enrolled500ConditionsAcute Decompensated Heart Failure
3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 8 syntheses or guidelines pooled it, 152 citations in OpenAlex.

  1. Pooled it
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  9. The Impact of Hospice Care on the Prognosis, Quality of Life, and Emotional Well-being of Patients With Chronic Heart Failure.Journal of hospice and palliative nursing : JHPN : the official journal of the Hospice and Palliative Nurses Association · 2025
    Trial
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  19. Impact of heart failure on skeletal muscle: an overview.Journal of geriatric cardiology : JGC · 2026
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jiayu YinDepartment of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Xiang LuDepartment of Geriatrics, Sir Run Run Hospital Affiliated to Nanjing Medical University, Nanjing, China.
Zhiyuan QianDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Weiting XuDepartment of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Xiang ZhouDepartment of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Second Affiliated Hospital of Soochow University · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcopenia is an age-related geriatric syndrome that is characterized by a progressive loss of muscle mass, strength and function. Chronic heart failure (CHF), the final stage of various cardiovascular diseases, may be closely correlated with the occurrence of sarcopenia. Accumulating evidence has demonstrated that CHF can promote the development of sarcopenia through multiple pathophysiological mechanisms, including malnutrition, inflammation, hormonal changes, oxidative stress, autophagy, and apoptosis. Additionally, CHF can aggravate the adverse outcomes associated with sarcopenia, including falls, osteoporosis, frailty, cachexia, hospitalization, and mortality. Sarcopenia and CHF are mutually interacting clinical syndromes. Patients with these two syndromes seem to endure a double burden, with no particularly effective way to hinder their progression. However, the combination of physical exercise, nutritional supplements, and drug therapy may counteract the development of these maladies. In this review, we will summarize the latest progress in the pathogenesis and treatment of sarcopenia in patients with CHF.

Indexed as

Chronic DiseaseExerciseFemaleHeart FailureHumansMaleSarcopeniachronic heart failurepathogenesissarcopeniatreatment

Identifiers

PMID31281529
PMCPMC6592172
OpenAlexW2949476999

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.