Evidence map›Paper›PMID 31281521›Full record

ArticleTheranostics2019

Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions.

Johannes Schwenck, Andreas Maurer, Birgit Fehrenbacher, Roman Mehling, Philipp Knopf, Natalie Mucha, Dennis Haupt, Kerstin Fuchs, Christoph M Griessinger, Daniel Bukala and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Cathepsin Z/X: Breaking Down the Known and Unknown.International journal of molecular sciences · 2026
    Review
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  13. Immunomodulatory and Antioxidant Activities of a Polysaccharide fromEvidence-based complementary and alternative medicine : eCAM · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 1 country.

Johannes SchwenckWerner Siemens Imaging Center, Department of Preclinical Imaging and RadiopharmacyEberhard Karls University, 72076 Tübingen, Germany.
Andreas MaurerWerner Siemens Imaging Center, Department of Preclinical Imaging and RadiopharmacyEberhard Karls University, 72076 Tübingen, Germany.
Birgit FehrenbacherDepartment of Dermatology, Eberhard Karls University, 72076 Tübingen, Germany.
Roman MehlingWerner Siemens Imaging Center, Department of Preclinical Imaging and RadiopharmacyEberhard Karls University, 72076 Tübingen, Germany.
Philipp KnopfWerner Siemens Imaging Center, Department of Preclinical Imaging and RadiopharmacyEberhard Karls University, 72076 Tübingen, Germany.
Natalie MuchaWerner Siemens Imaging Center, Department of Preclinical Imaging and RadiopharmacyEberhard Karls University, 72076 Tübingen, Germany.
Dennis HauptWerner Siemens Imaging Center, Department of Preclinical Imaging and RadiopharmacyEberhard Karls University, 72076 Tübingen, Germany.
Kerstin FuchsWerner Siemens Imaging Center, Department of Preclinical Imaging and RadiopharmacyEberhard Karls University, 72076 Tübingen, Germany.
Christoph M GriessingerWerner Siemens Imaging Center, Department of Preclinical Imaging and RadiopharmacyEberhard Karls University, 72076 Tübingen, Germany.
Daniel BukalaWerner Siemens Imaging Center, Department of Preclinical Imaging and RadiopharmacyEberhard Karls University, 72076 Tübingen, Germany.
Julia HolsteinDepartment of Dermatology, Eberhard Karls University, 72076 Tübingen, Germany.
Martin SchallerDepartment of Dermatology, Eberhard Karls University, 72076 Tübingen, Germany.
Irene Gonzalez MenendezDepartment of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany.
Kamran GhoreschiDepartment of Dermatology, Eberhard Karls University, 72076 Tübingen, Germany.
Leticia Quintanilla-MartinezDepartment of Pathology, Eberhard Karls University, 72076 Tübingen, Germany.
Michael GütschowPharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, 53121 Bonn, Germany.
Stefan LauferDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University, 72076 Tübingen, Germany.
Thomas ReinheckelInstitute of Molecular Medicine and Cell Research, Medical Faculty, Albert-Ludwigs University, 79085 Freiburg, Germany.
Martin RöckenDepartment of Dermatology, Eberhard Karls University, 72076 Tübingen, Germany.
Hubert KalbacherInterfaculty Institute of Biochemistry, Eberhard Karls University, 72076 Tübingen, Germany.
Bernd J PichlerWerner Siemens Imaging Center, Department of Preclinical Imaging and RadiopharmacyEberhard Karls University, 72076 Tübingen, Germany.
Manfred KneillingWerner Siemens Imaging Center, Department of Preclinical Imaging and RadiopharmacyEberhard Karls University, 72076 Tübingen, Germany.
University of Tübingen · DESiemens (Germany) · DECharité - Universitätsmedizin Berlin · DEGerman Cancer Research Center · DEUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cysteine-type cathepsins such as cathepsin B are involved in various steps of inflammatory processes such as antigen processing and angiogenesis. Here, we uncovered the role of cysteine-type cathepsins in the effector phase of T cell-driven cutaneous delayed-type hypersensitivity reactions (DTHR) and the implication of this role on therapeutic cathepsin B-specific inhibition.

Indexed as

Acute DiseaseAnimalsCatalytic DomainCathepsinsChronic DiseaseCysteineFemaleHumansHypersensitivity, DelayedInflammationMice, Inbred C57BLOptical ImagingPicryl ChlorideProtease InhibitorsSkinCathepsinsCysteinePicryl ChlorideProtease Inhibitorscathepsin Bdelayed-type hypersensitivityinflammationoptical imagingproteases

Identifiers

PMID31281521
PMCPMC6587341
OpenAlexW2950213703

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.