Evidence map›Paper›PMID 31281370›Full record

ArticleStem cells international2019

Fetal Dermal Mesenchymal Stem Cell-Derived Exosomes Accelerate Cutaneous Wound Healing by Activating Notch Signaling.

Xiao Wang, Ya Jiao, Yi Pan, Longxiao Zhang, Hongmin Gong, Yongjun Qi, Maoying Wang, Huiping Gong, Mingju Shao, Xinglei Wang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 5 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 5 syntheses or guidelines pooled it, 135 citations in OpenAlex.

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  4. Role of Exosomes in Dermal Wound Healing: A Systematic Review.The Journal of investigative dermatology · 2022
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Xiao WangSchool of Medicine, Shandong University, Jinan, Shandong 250012, China.
Ya JiaoSchool of Medicine, Shandong University, Jinan, Shandong 250012, China.
Yi PanSchool of Medicine, Shandong University, Jinan, Shandong 250012, China.
Longxiao ZhangDepartment of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China.
Hongmin GongSchool of Medicine, Shandong University, Jinan, Shandong 250012, China.
Yongjun QiSchool of Medicine, Shandong University, Jinan, Shandong 250012, China.
Maoying WangSchool of Medicine, Shandong University, Jinan, Shandong 250012, China.
Huiping GongDepartment of Emergency, The Second Hospital of Shandong University, Jinan, Shandong 250033, China.
Mingju ShaoDepartment of Emergency, The Second Hospital of Shandong University, Jinan, Shandong 250033, China.
Xinglei WangDepartment of Emergency, The Second Hospital of Shandong University, Jinan, Shandong 250033, China.
Duyin JiangSchool of Medicine, Shandong University, Jinan, Shandong 250012, China.ORCID 0000-0003-3233-1333
Shandong University · CNQingdao University · CNSecond Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fetal dermal mesenchymal stem cells (FDMSCs), isolated from fetal skin, are serving as a novel MSC candidate with great potential in regenerative medicine. More recently, the paracrine actions, especially MSC-derived exosomes, are being focused on the vital role in MSC-based cellular therapy. This study was to evaluate the therapeutic potential of exosomes secreted by FDMSCs in normal wound healing. First, the in vivo study indicated that FDMSC exosomes could accelerate wound closure in a mouse full-thickness skin wound model. Then, we investigated the role of FDMSC-derived exosomes on adult dermal fibroblast (ADFs). The results demonstrated that FDMSC exosomes could induce the proliferation, migration, and secretion of ADFs. We discovered that after treatment of exosomes, the Notch signaling pathway was activated. Then, we found that in FDMSC exosomes, the ligands of the Notch pathway were undetectable expect for Jagged 1, and the results of Jagged 1 mimic by peptide and knockdown by siRNA suggested that Jagged 1 may lead the activation of the Notch signal in ADFs. Collectively, our findings indicated that the FDMSC exosomes may promote wound healing by activating the ADF cell motility and secretion ability via the Notch signaling pathway, providing new aspects for the therapeutic strategy of FDMSC-derived exosomes for the treatment of skin wounds.

Identifiers

PMID31281370
PMCPMC6590601
OpenAlexW2950041750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.