Evidence map›Paper›PMID 31281321›Full record

ArticleFrontiers in immunology2019

Complex Bacterial Consortia Reprogram the Colitogenic Activity of

Isabella Lengfelder, Irina G Sava, Jonathan J Hansen, Karin Kleigrewe, Jeremy Herzog, Klaus Neuhaus, Thomas Hofmann, R Balfour Sartor, Dirk Haller

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 78 citations in OpenAlex.

  1. Review
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  7. Article
  8. Comprehensive analysis ofGut microbes · 2025
    Article
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  14. After Surgically Induced Remission, Ileal and Colonic Mucosa-Associated Microbiota Predicts Crohn's Disease Recurrence.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025
    Article
  15. Tracking the Prevalence of Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2024
    Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Isabella LengfelderChair of Nutrition and Immunology, Technische Universität München, Freising, Germany.
Irina G SavaChair of Nutrition and Immunology, Technische Universität München, Freising, Germany.
Jonathan J HansenDivision of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, United States.
Karin KleigreweBavarian Center for Biomolecular Mass Spectrometry, Technische Universität München, Freising, Germany.
Jeremy HerzogDivision of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, United States.
Klaus NeuhausZIEL - Institute for Food & Health, Technische Universität München, Freising, Germany.
Thomas HofmannBavarian Center for Biomolecular Mass Spectrometry, Technische Universität München, Freising, Germany.
R Balfour SartorDivision of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, United States.
Dirk HallerChair of Nutrition and Immunology, Technische Universität München, Freising, Germany.
Technical University of Munich · DEUniversity of North Carolina at Chapel Hill · USLeibniz-Institute for Food Systems Biology at the Technical University of Munich · DE

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
Role of IL-10 in APC Regulation of Protective vs. Pathogenic T Cell Responses toP01DK094779 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SARTOR, RYAN B · 2013 to 2023
$17.9M
National Gnotobiotic Rodent Resource CenterP40OD010995 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ryan B Sartor · 2012 to 2026
$9.7M
NIDDK NIH HHS P01 DK094779NIDDK NIH HHS P30 DK034987NIH HHS P40 OD010995
6 · The paper itself

Abstract

Inflammatory bowel diseases (IBD) are associated with compositional and functional changes of the intestinal microbiota, but specific contributions of individual bacteria to chronic intestinal inflammation remain unclear.

Indexed as

AnimalsColitisDisease Models, AnimalEnterococcus faecalisGram-Positive Bacterial InfectionsMiceMice, KnockoutMicrobial ConsortiaEnterococcus faecalisethanolamine utilizationgnotobiotic mouse modelsIBDIL-10 deficient mousemicrobial consortiumRNA sequencingSIHUMI

Identifiers

PMID31281321
PMCPMC6596359
OpenAlexW2950045601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.