ReviewFrontiers in microbiology2019
A Review of the Microbial Production of Bioactive Natural Products and Biologics.
Review in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 213 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
213 citing papers in PubMed, 544 citations in OpenAlex.
- Microbial Natural Products Targeting theMicroorganisms · 2026Review
- Microbial biobanking: safeguarding the tiny treasures for sustainable human welfare.Folia microbiologica · 2026Review
- From Discovery to Manufacturing: A Quantitative Review of Phosphonates and Strategies for High-Titer Production.Microorganisms · 2026Review
- Exopolysaccharide isolated from marine Bacillus subtilis strain AF2: production, characterization, purification and in vitro bioactivity.Biotechnology letters · 2026Article
- Article
- Harnessing the multifunctional bioagent Streptomyces sp. SP5 for Fusarium wilt suppression, metabolite-mediated antioxidant activity, and plant growth promotion.Scientific reports · 2026Article
- Genomic insights into probiotic functionality of Enterococcus hirae 3K isolated from Egyptian coastal sediments with special reference to exopolysaccharide production and antimicrobial activity potential.BMC microbiology · 2026Article
- Pamamycin Disrupts the Cell Envelope and Mitochondrial Potential to InhibitFoods (Basel, Switzerland) · 2026Article
- [Research Advances on Natural Products in Maintaining Oral Microecological Balance].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Elucidation of the growth phenotypes of 82 strains from theFrontiers in bioengineering and biotechnology · 2026Article
- Discovery of sugarnitriles A and B, and structural reassignment of SF-2140, from a sugarcane endophytic actinomyceteBeilstein journal of organic chemistry · 2026Article
- Microbial-Derived Anti-Cancer Compounds: Advances in Drug Discovery, Bioengineering, and Therapeutic Applications.Anti-cancer agents in medicinal chemistry · 2026Review
- Beyond antibiotics: the expanding horizon of microbial natural products.Frontiers in antibiotics · 2026Review
- Sulfur-Containing Microbial Natural Products and Their Role in Communal Interactions.Journal of natural products · 2025Review
- Article
- Freeze-Drying Effects on Viability and Cellular Stability in a Subset of Sourdough Lactic Acid Bacteria Strains.Current microbiology · 2025Article
- Exploring the potential of Bacillus spp. for secondary metabolite production through genome mining approaches.Journal, genetic engineering & biotechnology · 2025Article
- Antidiabetic effect of dried sweet potato extract with fermented lettuce extracts.Food science and biotechnology · 2025Article
- Antimicrobial potential and extracellular metabolite profiling of bichitrapur mangrove sediment derived Micromonospora sp. BSS-D-04 and Streptomyces sp. BSS-D-05 using LC-MS/MS and GC-MS analysis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Bioactive Compounds, Medicinal Benefits, and Contemporary Extraction Methods for Lemon Balm (Food science & nutrition · 2025Review
153 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A variety of organisms, such as bacteria, fungi, and plants, produce secondary metabolites, also known as natural products. Natural products have been a prolific source and an inspiration for numerous medical agents with widely divergent chemical structures and biological activities, including antimicrobial, immunosuppressive, anticancer, and anti-inflammatory activities, many of which have been developed as treatments and have potential therapeutic applications for human diseases. Aside from natural products, the recent development of recombinant DNA technology has sparked the development of a wide array of biopharmaceutical products, such as recombinant proteins, offering significant advances in treating a broad spectrum of medical illnesses and conditions. Herein, we will introduce the structures and diverse biological activities of natural products and recombinant proteins that have been exploited as valuable molecules in medicine, agriculture and insect control. In addition, we will explore past and ongoing efforts along with achievements in the development of robust and promising microorganisms as cell factories to produce biologically active molecules. Furthermore, we will review multi-disciplinary and comprehensive engineering approaches directed at improving yields of microbial production of natural products and proteins and generating novel molecules. Throughout this article, we will suggest ways in which microbial-derived biologically active molecular entities and their analogs could continue to inspire the development of new therapeutic agents in academia and industry.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.