Evidence map›Paper›PMID 31281019›Full record

ArticleBioorganic & medicinal chemistry letters2019

Bis(benzoyl) phosphate inactivators of beta-lactamase C from Mtb.

Dawanna S White, Cindy J Choy, Timothy W Moural, Stacy E Martin, Jing Wang, Samantha Gargaro, ChulHee Kang, Clifford E Berkman

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PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Dawanna S WhiteWashington State University, Department of Chemistry, Pullman, WA 99164-6340, United States.
Cindy J ChoyWashington State University, Department of Chemistry, Pullman, WA 99164-6340, United States.
Timothy W MouralWashington State University, Department of Chemistry, Pullman, WA 99164-6340, United States.
Stacy E MartinWashington State University, Department of Chemistry, Pullman, WA 99164-6340, United States.
Jing WangWashington State University, Tissue Imaging and Proteomics Laboratory, Pullman, WA 99164-4630, United States.
Samantha GargaroWashington State University, Department of Chemistry, Pullman, WA 99164-6340, United States.
ChulHee KangWashington State University, Department of Chemistry, Pullman, WA 99164-6340, United States.
Clifford E BerkmanWashington State University, Department of Chemistry, Pullman, WA 99164-6340, United States. Electronic address: cberkman@wsu.edu.
Washington State University · US

Funding

TRAINING IN BIOTECHNOLOGY: EMPHASIS ON PROTEIN CHEMISTRYT32GM008336 · NIGMS · WASHINGTON STATE UNIVERSITY · PI CALL, DOUGLAS R. · 1989 to 2023
$8.9M
Inactivating Inhibitors of Mycobacterium tuberculosis beta-lactamase BlaCR21AI115157 · NIAID · WASHINGTON STATE UNIVERSITY · PI BERKMAN, CLIFFORD · 2015 to 2016
$415k
NIAID NIH HHS R21 AI115157NIGMS NIH HHS T32 GM008336
6 · The paper itself

Abstract

The class A β-lactamase BlaC is a cell surface expressed serine hydrolase of Mycobacterium tuberculosis (Mtb), one of the causative agents for Tuberculosis in humans. Mtb has demonstrated increased susceptibility to β-lactam antibiotics upon inactivation of BlaC; thus, making BlaC a rational enzyme target for therapeutic agents. Herein, we present the synthesis and structure-activity-relationship data for the 1st-generation library of bis(benzoyl) phosphates (1-10). Substituent effects ranged from σ

Indexed as

beta-Lactamase Inhibitorsbeta-LactamasesCatalytic DomainCrystallography, X-RayEnzyme AssaysMolecular StructureMycobacterium tuberculosisOrganophosphatesPhosphorylationSerineSmall Molecule LibrariesStructure-Activity Relationshipbeta-Lactamase Inhibitorsbeta-LactamasesOrganophosphatesSerineSmall Molecule LibrariesBeta-lactamaseBlaCInhibitionPhosphorylationTuberculosis

Identifiers

PMID31281019
PMCPMC7654513
OpenAlexW2954861290

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.