Evidence map›Paper›PMID 31280564›Full record

ArticleJournal of the American Chemical Society2019

Enantioselective Synthesis of α-Allyl Amino Esters via Hydrogen-Bond-Donor Catalysis.

Andrew J Bendelsmith, Seohyun Chris Kim, Masayuki Wasa, Stéphane P Roche, Eric N Jacobsen

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Size and Polarizability as Design Principles for Stereoselective Catalysis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  2. Article
  3. Review
  4. Review
  5. Asymmetric organocatalytic synthesis of chiral homoallylic amines.Beilstein journal of organic chemistry · 2024
    Review
  6. Development of Enantioselective Lithium-Isothiourea-Boronate-Catalyzed Matteson Homologations.Synlett : accounts and rapid communications in synthetic organic chemistry · 2023
    Article
  7. Asymmetric Catalytic Friedel-Crafts Reactions of Unactivated Arenes.Journal of the American Chemical Society · 2023
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew J BendelsmithDepartment of Chemistry & Chemical Biology , Harvard University , Cambridge , Massachusetts 02138 , United States.
Seohyun Chris KimDepartment of Chemistry & Chemical Biology , Harvard University , Cambridge , Massachusetts 02138 , United States.ORCID 0000-0002-2230-1774
Masayuki WasaDepartment of Chemistry & Chemical Biology , Harvard University , Cambridge , Massachusetts 02138 , United States.ORCID 0000-0002-3309-9129
Stéphane P RocheDepartment of Chemistry & Biochemistry , Florida Atlantic University , Boca Raton , Florida 33431 , United States.ORCID 0000-0002-3019-2168
Eric N JacobsenDepartment of Chemistry & Chemical Biology , Harvard University , Cambridge , Massachusetts 02138 , United States.ORCID 0000-0001-7952-3661

Funding

CHIRAL COMPLEXES DESIGNED TO CATALYZE ORGANIC REACTIONSR01GM043214 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI JACOBSEN, ERIC N · 1991 to 2023
$9.4M
Chiral Catalysts Designed to Catalyze Organic ReactionsR37GM043214 · NIGMS · HARVARD UNIVERSITY · PI JACOBSEN, ERIC N · 2002 to 2011
$6.6M
NIGMS NIH HHS R01 GM043214NIGMS NIH HHS R37 GM043214
6 · The paper itself

Abstract

We report a chiral-squaramide-catalyzed enantio- and diastereoselective synthesis of α-allyl amino esters. The optimized protocol provides access to

Indexed as

AlkenesAlkylationAllyl CompoundsAmino AcidsCatalysisEstersHydrogen BondingQuinineSchiff BasesSilanesStereoisomerismAlkenesAllyl CompoundsallylsilaneAmino AcidsEstersQuinineSchiff BasesSilanessquaramide

Identifiers

PMID31280564
PMCPMC7293823

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.