ArticleAnalytical and bioanalytical chemistry2019
Accurate mass and retention time library of serum lipids for type 1 diabetes research.
Article in Analytical and bioanalytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 22 citations in OpenAlex.
- Exploration of the structural diversity and distribution pattern of gangliosides and sulfatides in mouse brain tissues and biomarkers for Parkinson's Disease.Lipids in health and disease · 2026Article
- A Practical Roadmap for Clinical Translation of Metabolic Biomarkers: A Review.International journal of molecular sciences · 2026Review
- Challenges in Lipidomics Biomarker Identification: Avoiding the Pitfalls and Improving Reproducibility.Metabolites · 2024Article
- Multi-omics Analyses Reveal Function of Apolipoprotein E in Alternative Splicing and Tumor Immune Microenvironment in Kidney Renal Clear Cell Carcinoma via Pan-cancer Analysis.Cell biochemistry and biophysics · 2024Article
- Recent Analytical Methodologies in Lipid Analysis.International journal of molecular sciences · 2024Review
- Rapid quantification of 50 fatty acids in small amounts of biological samples for population molecular phenotyping.Biophysics reports · 2023Article
- Hepatoviruses promote very-long-chain fatty acid and sphingolipid synthesis for viral RNA replication and quasi-enveloped virus release.Science advances · 2023Article
- Nanocapillary sampling coupled to liquid chromatography mass spectrometry delivers single cell drug measurement and lipid fingerprints.The Analyst · 2023Article
- Identification, mapping and relative quantitation of SARS-CoV-2 Spike glycopeptides by Mass-Retention Time Fingerprinting.Communications biology · 2021Article
- Developing an integrated microfluidic and miniaturized electrochemical biosensor for point of care determination of glucose in human plasma samples.Analytical and bioanalytical chemistry · 2021Article
- A UPLC-MRM-MS method for comprehensive profiling of Amadori compound-modified phosphatidylethanolamines in human plasma.Analytical and bioanalytical chemistry · 2021Article
- [Blood lipid metabolic profile of overweight/obese boys aged 9-12 years].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Dysregulated lipid species are linked to various disease pathologies and implicated as potential biomarkers for type 1 diabetes (T1D). However, it is challenging to comprehensively profile the blood specimen lipidome with full structural details of every lipid molecule. The commonly used reversed-phase liquid chromatography-tandem mass spectrometry (RPLC-MS/MS)-based lipidomics approach is powerful for the separation of individual lipid species, but lipids belonging to different classes may still co-elute and result in ion suppression and misidentification of lipids. Using offline mixed-mode and RPLC-based two-dimensional separations coupled with MS/MS, a comprehensive lipidomic profiling was performed on human sera pooled from healthy and T1D subjects. The elution order of lipid molecular species on RPLC showed good correlations to the total number of carbons in fatty acyl chains and total number of double bonds. This observation together with fatty acyl methyl ester analysis was used to enhance the confidence of identified lipid species. The final T1D serum lipid library database contains 753 lipid molecular species with accurate mass and RPLC retention time uniquely annotated for each of the species. This comprehensive human serum lipid library can serve as a database for high-throughput RPLC-MS-based lipidomic analysis of blood samples related to T1D and other childhood diseases. Graphical abstract.
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