Evidence map›Paper›PMID 31280464›Full record

ArticleProbiotics and antimicrobial proteins2020

In Silico Prediction and In Vitro Assessment of Multifunctional Properties of Postbiotics Obtained From Two Probiotic Bacteria.

J E Aguilar-Toalá, F G Hall, U C Urbizo-Reyes, H S Garcia, B Vallejo-Cordoba, A F González-Córdova, A Hernández-Mendoza, A M Liceaga

Abstract read
PubMed Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 81 citations in OpenAlex.

  1. Gut-Brain Signaling in Parkinson's Disease: A Narrative Review.International journal of molecular sciences · 2026
    Review
  2. Emerging Nonthermal Technologies for the Production of Postbiotics.Comprehensive reviews in food science and food safety · 2025
    Review
  3. Review
  4. Review
  5. Effects ofFood chemistry: X · 2025
    Article
  6. Genomic Face-off: AnCurrent genomics · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Gut Microbiota and Immunotherapy.Frontiers in microbiology · 2022
    Review
  16. Influence of the microbiome on solid organ transplant survival.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021
    Review
  17. Article
  18. Review
  19. Signaling Molecules of Human Skin Cells as the Targets for Injection Cosmetology.Clinical, cosmetic and investigational dermatology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

J E Aguilar-ToaláLaboratorio de Química y Biotecnología de Productos Lácteos, Centro de Investigación en Alimentación y Desarrollo A.C. (CIAD), Carretera a La Victoria km. 0.6, 83304, Hermosillo, Sonora, Mexico.
F G HallDepartment of Food Science, Purdue University, 745 Agriculture Mall Dr, West Lafayette, IN, 47907, USA.
U C Urbizo-ReyesDepartment of Food Science, Purdue University, 745 Agriculture Mall Dr, West Lafayette, IN, 47907, USA.
H S GarciaUNIDA Tecnológico Nacional de México, Instituto Tecnológico de Veracruz, M.A. de Quevedo 2279, Col. Formando Hogar, 91897, Veracruz, Veracruz, Mexico.
B Vallejo-CordobaLaboratorio de Química y Biotecnología de Productos Lácteos, Centro de Investigación en Alimentación y Desarrollo A.C. (CIAD), Carretera a La Victoria km. 0.6, 83304, Hermosillo, Sonora, Mexico.
A F González-CórdovaLaboratorio de Química y Biotecnología de Productos Lácteos, Centro de Investigación en Alimentación y Desarrollo A.C. (CIAD), Carretera a La Victoria km. 0.6, 83304, Hermosillo, Sonora, Mexico.
A Hernández-MendozaLaboratorio de Química y Biotecnología de Productos Lácteos, Centro de Investigación en Alimentación y Desarrollo A.C. (CIAD), Carretera a La Victoria km. 0.6, 83304, Hermosillo, Sonora, Mexico. ahernandez@ciad.mx.
A M LiceagaDepartment of Food Science, Purdue University, 745 Agriculture Mall Dr, West Lafayette, IN, 47907, USA. aliceaga@purdue.edu.ORCID 0000-0003-0994-1205
Purdue University West Lafayette · USCentro de Investigación en Alimentación y Desarrollo · MXTecnológico Nacional de México · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, a global metabolite profile using Raman spectroscopy analysis was obtained in order to predict, by an in silico prediction of activity spectra for substance approach, the bioactivities of the intracellular content (IC) and cell wall (CW) fractions obtained from Lactobacillus casei CRL 431 and Bacillus coagulans GBI-30 strains. Additionally, multifunctional in vitro bioactivity of IC and CW fractions was also assessed. The metabolite profile revealed a variety of compounds (fatty acids, amino acids, coenzyme, protein, amino sugars), with significant probable activities (Pa > 0.7) as immune-stimulant, anti-inflammatory, neuroprotective, antiproliferative, immunomodulator, and antineoplastic, among others. Moreover, in vitro assays exhibited that both IC and CW fractions presented angiotensin-converting enzyme-inhibitory (> 90%), chelating (> 79%), and antioxidant (ca. 22-57 cellular antioxidant activity units) activities. Our findings based on in silico and in vitro analyses suggest that L. casei CRL 431 and B. coagulans GBI-30 strains appear to be promising sources of postbiotics and may impart health benefits by their multifunctional properties.

Indexed as

MetabolomeBacillus coagulansComputational BiologyLacticaseibacillus caseiProbioticsIn silico predictionLactobacillusMultifunctional bioactivityPostbiotics

Identifiers

PMID31280464
OpenAlexW2955573329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.